Skip to main content

Table 2 Classification of microscopic lesions and other microscopic abnormalities: low dose NMU-treated whole mounted mammary glands

From: Histological analysis of low dose NMU effects in the rat mammary gland

 

12 weeks

22 weeks

25 and 30 weeks§

Dose

(mg/kg BW)

10

20

30

50

10

20

30

50

10

20

30

50

Lactational change

0

0

0

0

0

0

1

2

2

4

1

0

Increased acini #

0

0

0

3

0

1

1

1

0

1

0

0

Hyperplasia

0

0

1

1

0

0

0

2

0

3

3

1

DCIS

0

0

0

1

0

1

1

0

0

2

7

18

  1. §30 mg/kg BW animals were sacrificed at 30 weeks p.i. whereas 50 mg/kg BW animals were sacrificed at 25 weeks p.i. One abnormal structure per animal was selected for analysis at these time points compared to all structures being analyzed for all other groups.