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Table 2 Classification of microscopic lesions and other microscopic abnormalities: low dose NMU-treated whole mounted mammary glands

From: Histological analysis of low dose NMU effects in the rat mammary gland

  12 weeks 22 weeks 25 and 30 weeks§
Dose (mg/kg BW) 10 20 30 50 10 20 30 50 10 20 30 50
Lactational change 0 0 0 0 0 0 1 2 2 4 1 0
Increased acini # 0 0 0 3 0 1 1 1 0 1 0 0
Hyperplasia 0 0 1 1 0 0 0 2 0 3 3 1
DCIS 0 0 0 1 0 1 1 0 0 2 7 18
  1. §30 mg/kg BW animals were sacrificed at 30 weeks p.i. whereas 50 mg/kg BW animals were sacrificed at 25 weeks p.i. One abnormal structure per animal was selected for analysis at these time points compared to all structures being analyzed for all other groups.