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Table 2 Compatibility Study Results

From: Confocal Microscopy of Unfixed Breast Needle Core Biopsies: A Comparison to Fixed and Stained Sections

Sample† Preparation* Protocol ER PR HER 2/nu Pathologic diagnosis
   Normal Cancer Normal Cancer Normal Cancer  
1A 1 NA + NA + NA - DCIS
1B 2 NA + NA - NA - DCIS
1C 3 NA + NA + NA - DCIS
2A 1 NA - NA - NA + DCIS
2B 4 NA - NA - NA + DCIS
2C 5 NA - NA - NA + DCIS
3A 1 + NA + NA NA NA Normal
3B 6 + NA + NA NA NA Normal
3C 5 + NA + NA NA NA Normal
5A 1 NA - NA - NA + DCIS
5B 5 NA - NA - NA + DCIS
5C 4 NA - NA - NA + DCIS
6A 1 + - + - NA - Invasive DC
6B 4 NA - NA - NA - Invasive DC
6C 5 NA - NA - NA - Invasive DC
6D 8 NA - NA - NA - Invasive DC
7A 1 + NA + NA NA NA Normal
7B 9 - NA + NA NA NA Normal
7C 10 - NA + NA NA NA Normal
7D 5 + NA + NA NA NA Normal
8A 5 + weak NA + NA NA NA Normal (atrophic)
8B 1 + weak NA + NA NA NA Normal (atrophic)
8C 1 + weak NA + NA NA NA Normal (atrophic)
9A 5 NA - NA - NA - Invasive DC
9B 1 NA - NA - NA - Invasive DC
9C 1 NA - NA - NA - Invasive DC
10A 5 + NA + NA NA NA Normal
10B 3 + NA + NA NA NA Normal
10C 11 + - + - NA - Normal and DCIS
10D 1 + - + - NA - Normal and DCIS
  1. †While 10 cases were studied, sample 4 was excluded due to inadequate tissue handling. * Preparation Protocol: Preparation 1: Control; Preparation 2: Unbuffered 10% citric acid (1 min) and saline bath (5 min); Preparation 3: Buffered 10% citric acid (1 min) and glycerin (3 min) without saline; Preparation 4: Glycerin (3 min) without saline; Preparation 5: Buffered 10% citric acid (1 min) and glycerin (3 min) and saline bath; Preparation 6: Buffered 10% citric acid (1 min) without saline bath; Preparation 7: 5% Acetic acid (5 min) without saline bath; Preparation 8: Glycerin (3 min) with saline bath (5 min); Preparation 9: Unbuffered 10% citric acid (1 min) and glycerin (3 min) with saline bath (5 min); Preparation 10: 5% Acetic acid (1 min) and glycerin (3 min) without saline bath; Preparation 11: Mixture of buffered 10% citric acid and 5% acetic acid (1 min) and glycerin (3 min) without saline bath.