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Table 4 Association between GNRHR haplotypes and breast cancer risk in the BPC3 study.

From: Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)

Haplotype Cases (%) Controls (%) OR (95% CI)a p value
Block 1     
hAGA 2,426 (43) 3,161 (42) 1.00 (ref.)  
hGGT 2,060 (36) 2,806 (37) 0.98 (0.93–1.03) 0.491
hGAT 473 (8) 620 (8) 1.02 (0.93–1.11) 0.712
hAGT 397 (7) 557 (7) 0.96 (0.87–1.06) 0.433
hGGA 307 (5) 400 (5) 0.97 (0.87–1.07) 0.522
Freq<3% 4 (<1) 6 (<1) 0.83 (0.31–2.25) 0.720
Block 2     
hATTA 2,997 (53) 3,908 (52) 1.00 (ref.)  
hGCTG 1,178 (21) 1,630 (22) 0.99 (0.92–1.06) 0.342
hATCG 667 (12) 937 (12) 1.00 (0.92–1.09) 0.731
hATTG 478 (8) 633 (8) 1.01 (0.89–1.14) 0.949
hACTG 177 (3) 214 (3) 0.98 (0.85–1.15) 0.862
hGCCG 150 (3) 206 (3) 1.11 (0.76–1.62) 0.836
Freq<3% 21 (<1) 22 (<1) 0.98 (0.93–1.03) 0.579
  1. aOdds ratios and 95% confidence intervals, calculated by unadjusted logistic regression analysis conditional on the matching variables