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Table 4 Association between GNRHR haplotypes and breast cancer risk in the BPC3 study.

From: Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)

Haplotype

Cases (%)

Controls (%)

OR (95% CI)a

p value

Block 1

    

hAGA

2,426 (43)

3,161 (42)

1.00 (ref.)

 

hGGT

2,060 (36)

2,806 (37)

0.98 (0.93–1.03)

0.491

hGAT

473 (8)

620 (8)

1.02 (0.93–1.11)

0.712

hAGT

397 (7)

557 (7)

0.96 (0.87–1.06)

0.433

hGGA

307 (5)

400 (5)

0.97 (0.87–1.07)

0.522

Freq<3%

4 (<1)

6 (<1)

0.83 (0.31–2.25)

0.720

Block 2

    

hATTA

2,997 (53)

3,908 (52)

1.00 (ref.)

 

hGCTG

1,178 (21)

1,630 (22)

0.99 (0.92–1.06)

0.342

hATCG

667 (12)

937 (12)

1.00 (0.92–1.09)

0.731

hATTG

478 (8)

633 (8)

1.01 (0.89–1.14)

0.949

hACTG

177 (3)

214 (3)

0.98 (0.85–1.15)

0.862

hGCCG

150 (3)

206 (3)

1.11 (0.76–1.62)

0.836

Freq<3%

21 (<1)

22 (<1)

0.98 (0.93–1.03)

0.579

  1. aOdds ratios and 95% confidence intervals, calculated by unadjusted logistic regression analysis conditional on the matching variables