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Table 3 Association between GNRHR htSNPs and breast cancer risk in the BPC3 study.

From: Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)

SNP Genotype Cases (%) Controls (%) OR (95% CI)a p value
rs13138607 G/G 1,413 (26) 1,948 (27) 1.00 (ref.)  
  G/A 2,696 (49) 3,550 (48) 1.03 (0.95–1.11) 0.484
  A/A 1,380 (25) 1,829 (25) 1.01 (0.92–1.11) 0.789
      ptrend = 0.781
rs4986942 G/G 4,650 (84) 6,200 (84) 1.00 (ref.)  
  G/A 867 (16) 1,136 (15) 1.04 (0.95–1.14) 0.350
  A/A 34 (1) 41 (1) 0.99 (0.66–1.49) 0.967
      ptrend = 0.402
rs10031252 T/T 1,503 (27) 2,093 (28) 1.00 (ref.)  
  T/A 2,694 (49) 3,566 (48) 1.02 (0.94–1.10) 0.640
  A/A 1,324 (24) 1,701 (23) 1.02 (0.93–1.12) 0.641
      ptrend = 0.637
rs3822196 A/A 3,259 (59) 4,202 (58) 1.00 (ref.)  
  A/G 1,872 (34) 2,589 (36) 0.96 (0.89–1.03) 0.223
  G/G 350 (6) 480 (7) 0.97 (0.8–41.11) 0.622
      ptrend = 0.273
rs3796718 T/T 2,951 (55) 3,868 (54) 1.00 (ref.)  
  T/C 2,053 (38) 2,761 (38) 0.98 (0.92–1.05) 0.642
  C/C 409 (8) 571 (8) 0.96 (0.84–1.09) 0.497
      ptrend = 0.461
rs1843593 T/T 4,012 (73) 5,277 (72) 1.00 (ref.)  
  T/C 1,357 (25) 1,843 (25) 1.01 (0.93–1.09) 0.831
  C/C 122 (2) 188 (3) 0.98 (0.79–1.22) 0.848
      ptrend = 0.942
rs2630488 A/A 1,530 (29) 1,959 (27) 1.00 (ref.)  
  A/G 2,618 (49) 3,489 (49) 1.00 (0.92–1.08) 0.942
  G/G 1,200 (22) 1,694 (24) 0.96 (0.88–1.06) 0.436
      ptrend = 0.458
  1. aOdds ratios and 95% confidence intervals, calculated by unadjusted logistic regression analysis conditional on the matching variables