Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)

Table 3 Association between GNRHR htSNPs and breast cancer risk in the BPC3 study.

SNP	Genotype	Cases (%)	Controls (%)	OR (95% CI)^a	p value
rs13138607	G/G	1,413 (26)	1,948 (27)	1.00 (ref.)
	G/A	2,696 (49)	3,550 (48)	1.03 (0.95–1.11)	0.484
	A/A	1,380 (25)	1,829 (25)	1.01 (0.92–1.11)	0.789
					p_trend = 0.781
rs4986942	G/G	4,650 (84)	6,200 (84)	1.00 (ref.)
	G/A	867 (16)	1,136 (15)	1.04 (0.95–1.14)	0.350
	A/A	34 (1)	41 (1)	0.99 (0.66–1.49)	0.967
					p_trend = 0.402
rs10031252	T/T	1,503 (27)	2,093 (28)	1.00 (ref.)
	T/A	2,694 (49)	3,566 (48)	1.02 (0.94–1.10)	0.640
	A/A	1,324 (24)	1,701 (23)	1.02 (0.93–1.12)	0.641
					p_trend = 0.637
rs3822196	A/A	3,259 (59)	4,202 (58)	1.00 (ref.)
	A/G	1,872 (34)	2,589 (36)	0.96 (0.89–1.03)	0.223
	G/G	350 (6)	480 (7)	0.97 (0.8–41.11)	0.622
					p_trend = 0.273
rs3796718	T/T	2,951 (55)	3,868 (54)	1.00 (ref.)
	T/C	2,053 (38)	2,761 (38)	0.98 (0.92–1.05)	0.642
	C/C	409 (8)	571 (8)	0.96 (0.84–1.09)	0.497
					p_trend = 0.461
rs1843593	T/T	4,012 (73)	5,277 (72)	1.00 (ref.)
	T/C	1,357 (25)	1,843 (25)	1.01 (0.93–1.09)	0.831
	C/C	122 (2)	188 (3)	0.98 (0.79–1.22)	0.848
					p_trend = 0.942
rs2630488	A/A	1,530 (29)	1,959 (27)	1.00 (ref.)
	A/G	2,618 (49)	3,489 (49)	1.00 (0.92–1.08)	0.942
	G/G	1,200 (22)	1,694 (24)	0.96 (0.88–1.06)	0.436
					p_trend = 0.458

^aOdds ratios and 95% confidence intervals, calculated by unadjusted logistic regression analysis conditional on the matching variables

ISSN: 1471-2407