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Table 1 Association between GNRH1 htSNPs and breast cancer risk in the BPC3 study.

From: Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)

SNP Genotype Cases (%) Controls (%) OR (95% CI)a p value
rs2709618 G/G 2,094 (38) 2,771 (38) 1.00 (ref.)  
  G/A 2,547 (46) 3,412 (46) 1.00 (0.93–1.08) 0.942
  A/A 868 (16) 1,163 (16) 1.00 (0.90–1.10) 0.927
      ptrend = 0.958
rs6185 C/C 3,023 (56) 4,036 (56) 1.00 (ref.)  
  C/G 1,963 (36) 2,684 (37) 0.98 (0.91–1.05) 0.597
  G/G 418 (8) 545 (8) 0.99 (0.87–1.13) 0.889
      ptrend = 0.695
rs1812594 T/T 3,424 (64) 4,565 (65) 1.00 (ref.)  
  T/C 1,730 (32) 2,158 (31) 1.08 (1.00–1.16) 0.040
  C/C 203 (4) 285 (4) 0.98 (0.82–1.17) 0.825
      ptrend = 0.156
  1. aOdds ratios and 95% confidence intervals, calculated by unadjusted logistic regression analysis conditional on the matching variables