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Table 1 Association between GNRH1 htSNPs and breast cancer risk in the BPC3 study.

From: Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)

SNP

Genotype

Cases (%)

Controls (%)

OR (95% CI)a

p value

rs2709618

G/G

2,094 (38)

2,771 (38)

1.00 (ref.)

 
 

G/A

2,547 (46)

3,412 (46)

1.00 (0.93–1.08)

0.942

 

A/A

868 (16)

1,163 (16)

1.00 (0.90–1.10)

0.927

     

ptrend = 0.958

rs6185

C/C

3,023 (56)

4,036 (56)

1.00 (ref.)

 
 

C/G

1,963 (36)

2,684 (37)

0.98 (0.91–1.05)

0.597

 

G/G

418 (8)

545 (8)

0.99 (0.87–1.13)

0.889

     

ptrend = 0.695

rs1812594

T/T

3,424 (64)

4,565 (65)

1.00 (ref.)

 
 

T/C

1,730 (32)

2,158 (31)

1.08 (1.00–1.16)

0.040

 

C/C

203 (4)

285 (4)

0.98 (0.82–1.17)

0.825

     

ptrend = 0.156

  1. aOdds ratios and 95% confidence intervals, calculated by unadjusted logistic regression analysis conditional on the matching variables