Mammaglobin B is an independent prognostic marker in epithelial ovarian cancer and its expression is associated with reduced risk of disease recurrence

Table 2 Association between MGB-2 mRNA expression and clinicopathologic variables in 98 patients.

Parameter	Fold change	95%CI	p-value
Age at diagnosis (y)
> 40 vs ≤ 40	1.60	0.38 – 6.62	0.517
Histological type
clear-cell vs endometrioid	0.47	0.09 – 2.40	0.361
undifferentiated vs endometrioid	0.05	0.01 – 0.44	< 0.010
serous metastases vs endometriod	0.14	0.04 – 0.53	< 0.010
mixed vs endometriod	0.28	0.06 – 1.23	0.090
mucinous vs endometrioid	0.34	0.03 – 4.08	0.387
serous vs endometrioid	0.26	0.07 – 0.91	0.036
FIGO stage
> IIB vs ≤ IIB	0.19	0.07 – 0.51	< 0.010
Histological grade
G2 vs G1	0.47	0.04 – 4.99	0.642^$
G3 vs G1	0.22	0.03 – 1.68	0.159^$
G2&G3 vs G1	0.32	0.04 – 2.61	0.337^$
Residual tumor (TR), cm
TR ≥ 0.5 vs TR = 0	0.38	0.16 – 0.93	0.034
Ascites
yes vs no	0.37	0.16 – 0.83	0.017
Lymph nodal involvement
positive vs negative	0.53	0.19 – 1.49	0.228
Preoperative CA125 serum level
≥ Threshold vs < Threshold**	0.19	0.04 – 0.81	0.026

** Threshold = 200 U/ml for pre-menopausal patients & Threshold = 35 U/ml for post-menopausal patients.
$ corrected for multiple testing.

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