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Table 2 Outcome according to microsatellite instability and mismatch repair deficiency stratified by disease stage.

From: Microsatellite instability in colorectal cancer and association with thymidylate synthase and dihydropyrimidine dehydrogenase expression

   Recurrence free survival Overall survival
  No. Events Hazard ratio (95% CI) P Events Hazard ratio (95% CI) P
Microsatellite status*          
   All stages 311 113 0.4 0.2–0.7 0.002 138 0.5 0.2–0.9 0.02
   II 32 8 - - - 13 - - -
   III 244 81 0.5 0.3–0.9 0.04 101 0.6 0.3–1.2 0.2
   IV 35 24 - - - 24 - - -
Mismatch repair competence*          
   All stages 306 149 0.5 0.3–0.9 0.006 132 0.6 0.3–1.0 0.04
   II 36 14 - - - 13 - - -
   III 241 112 0.6 0.4–1.0 0.04 100 0.7 0.4–1.2 0.2
   IV 29 23 - - - 19 - - -
  1. *hazard ratios for instable (MSI) relative to stable (MSS) microsatellites, and mismatch repair deficient relative to proficient tumors.