Table 4 Logistic regression analysis to identify predictors of BRCA mutations
Characteristics | No. of cases | BRCA+ carriers | OR (95% CI) | P |
|---|---|---|---|---|
Age of Onset | ||||
< 45 years | 139 | 21 (15%) | 1.8 (1.05–4.28) | 0.046 |
> 45 years | 209 | 14 (7%) | ||
Risk criteria | ||||
high-risk family | 131 | 23 (18%) | 3.2 (1.51–6.67) | 0.002 |
no high risk family | 217 | 12 (6%) | ||
Ovarian cancer in family | ||||
presence | 23 | 6 (26%) | 3.7 (1.44–9.40) | 0.006 |
absence | 244 | 27 (11%) | ||
Bilaterality | ||||
presence | 36 | 8 (22%) | 2.4 (1.05–5.39) | 0.038 |
absence | 228 | 25 (11%) | ||
T | ||||
T1 | 151 | 12 (8%) | 2.23 (0.57–8.82) | 0.251 |
T2 | 70 | 10 (14%) | ||
T3-4 | 26 | 4 (15%) | ||
N | ||||
N- | 126 | 15 (12%) | 1.02 (0.39–2.67) | 0.963 |
N+ | 112 | 13 (12%) | ||
M | ||||
M0 | 201 | 20 (10%) | 1.33 (0.15–11.7) | 0.797 |
M1 | 24 | 3 (12%) | ||
Tumor Grading | ||||
G1-2 | 171 | 9 (5%) | 11.3 (3.38–37.6) | < 0.001 |
G3-4 | 33 | 12 (36%) | ||
Estrogen Receptor (ER) | ||||
ER- | 55 | 16 (29%) | 0.18 (0.06–0.53) | 0.002 |
ER+ | 102 | 10 (10%) | ||
Progesteron Receptor (PR) | ||||
PR- | 81 | 21 (26%) | 0.22 (0.07–0.66) | 0.007 |
PR+ | 67 | 6 (9%) |