Kaplan-Meier survival plots for the individual genes in AP4. The partition defined by each of the AP4 genes individually is a significant predictor of metastasis, however each is less significant than AP4. In (a), MKI67 denotes the probe 212022_s_at and in (c), MKI67.2 denotes the probe 212020_s_at. The sample set is the same set used in Figure 3, namely, the union of the ER+ samples in OXFD, GUYT, MZ and GUYT2. The hazard ratios, with 95% confidence intervals, for these genes are: MKI67, 2.90 (1.84 – 4.57); CDC6, 2.47 (1.62 – 3.75); MKI67.2, 1.84 (1.20 – 2.82); SPAG5, 2.91 (1.92 – 4.43). These are significantly smaller than the hazard ratio of 3.76 for AP4.