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Table 1 Percentage of cells in the cell cycle phases after 24 hours incubation with 10 μM JAI-51

From: A novel chalcone derivative which acts as a microtubule depolymerising agent and an inhibitor of P-gp and BCRP in in-vitro and in-vivoglioblastoma models

Cell cycle phase U118C U118T U138C U138T U373C U373T LN229C LN229T GL26C GL26T
G0/G1 60 ± 9 30 ± 5 * 54 ± 6 32 ± 6 * 54 ± 4 21 ± 3 * 53 ± 5 12 ± 4 * 55 ± 8 30 ± 5 *
S 18 ± 2 15 ± 3 10 ± 2 9 ± 2 20 ± 2 15 ± 2 18 ± 3 19 ± 4 22 ± 3 10 ± 3
G2/M 22 ± 3 55 ± 7 * 34 ± 7 58 ± 6 * 26 ± 3 64 ± 6 * 28 ± 3 68 ± 6 * 23 ± 4 60 ± 8 *
  1. Glioblastoma cells were cultured for 24 hours without (C) or with 10 μM JAI-51 (T) before being stained with propidium iodide. DNA content was analyzed by flow-cytometry and the percentage of cells in each phase of the cell cycle was obtained by using Modfit program. Numbers ± SD indicate the percentage of cells and are the mean of 3 to 5 experiments. * P < 0.05 (treated versus control).