TY - JOUR AU - Zare, Maryam AU - Jazii, Ferdous Rastgar AU - Alivand, Mohammad Reza AU - Nasseri, Negin Karimi AU - Malekzadeh, Reza AU - Yazdanbod, Mansour PY - 2009 DA - 2009/01/17 TI - Qualitative analysis of Adenomatous Polyposis Coli promoter: Hypermethylation, engagement and effects on survival of patients with esophageal cancer in a high risk region of the world, a potential molecular marker JO - BMC Cancer SP - 24 VL - 9 IS - 1 AB - Squamous cell carcinoma of esophagus (SCCE) occurs at a high incidence rate in certain parts of the world. This feature necessitates that different aspects of the disease and in particular genetic characteristics be investigated in such regions. In addition, such investigations might lead to achievement of molecular markers helpful for early detection, successful treatment and follow up of the disease. Adenomatous Polyposis Coli (APC) promoter hypermethylation has been shown to be a suitable marker for both serum and solid tumors of adenocarcinoma of esophagus. We investigated the status of APC promoter hypermethylation in Iranian patients, compared the results with the former studies, and evaluated its applicability as a candidate molecular marker by examining association between survival of SCCE patients and APC promoter methylation. SN - 1471-2407 UR - https://doi.org/10.1186/1471-2407-9-24 DO - 10.1186/1471-2407-9-24 ID - Zare2009 ER -