Regulation of MYCNexpression in human neuroblastoma cells

BMC Cancer

Table 2 Patient characteristics.

Pt	Age^a	Sex	Diagnosis	Localization	Histology^b	MYCN^c	Treatment and follow-up	Status
1.	3 mnts	F	NB IV S	Adnex and liver metastasis	UD	No	05/'01 surgery + chemo	Alive
2.	3 yrs	M	NB IV	Supraclavicular and BM metastases	PD	No	02/'03 surgery + chemo 07/'03 chemo, SCR + RT	Alive
3.	4 mnts	M	NB II	Pos. lymphnodes with unknown primary tumor	PD	No	01/'03 surgery + chemo	Alive
4.	5 mnts	M	NB IV S	Spine and bone/liver metastases	PD	No	01/'01 surgery + chemo	Alive
5.	14 mnts	F	NB II	Spine	PD	No	02/'04 surgery + chemo	Alive
6.	4 mnts	F	NB II	Adnex	PD	No	07/'01 surgery + chemo	Alive
7.	2 yrs	F	NB III	Adnex	D	No	01/'02 chemo + sugery	Alive
8.	3 mnts	M	NB I	Adnex	D	No	02/'02 Surgery	Alive
9.	2 yrs	M	NB IV	Adnex with bone/BM metastases	D^d	No	12/'03 chemo, SCR + RT 10/'04 relapse treatment	d.o.d.
10.	8 mnts	F	NB III	Spine	PD	No	04/'02 surgery + chemo 12/'02 Surgery spinal relapse	Alive
11.	18 mnts	F	NB III	Adnex	UD^d	20×	09/'98 MIBG, chemo + surgery 04/'99 chemo and SCR	d.o.d.
12.	2 yrs	M	NB IV	Adnex and bone metastases	PD^d	37 ×	07/'98 surgery, chemo + SCR	d.o.d.
13.	6 yrs	M	NB III	Adnex	UD	27 ×	01/'00 surgery, chemo + SCR 11/'03 surgery, chemo + RT	d.o.d.
14.	19 mnts	M	NB IV	Adnex and spine metastasis	UD	49 ×	03/'98 MIBG, chemo + surgery	d.o.d.
15.	18 mnts	M	NB IV	Adnex and multiple distal metastases	n.d.	139 ×	06/'99 chemo + RT	d.o.d.
16.	16 mnts	M	NB IV	Adnex and multiple distal metastases	UD	74 ×	01/'97 chemo + surgery	d.o.d.

^aAge at diagnosis
^bNeuroblastoma differentiation as assessed by pathologist. D = differentiated; PD = poorly differentiated; UD = undifferentiated
^c MYCN genomic amplification, as determined with qPCR
^dPatient has been treated before surgery
BM = bone marrow; d.o.d. = death of disease; MIBG = meta-iodobenzylguanidine; SCR = stem cell rescue; RT = radiotherapy.

ISSN: 1471-2407