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Table 3 Haplotype-pairs effects of TNF genetic polymorphisms for gastric cancer stratified by smoking status in a nested case-control study within the KMCC 19,688 enrolled cohort members.

From: The role of TNFgenetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study

Haplotype pairs

Total

Non-smokers

Smokers

 

Case

Control

OR (95% CI)a

Case

Control

OR (95% CI)b

Case

Control

OR (95% CI)b

Block1: TNF α-1031, -863, -857 c

   TCC-TCC

25 (34)

132 (44)

1.0 (reference)

11 (50)

58 (45)

1.0 (reference)

14 (27)

73 (44)

1.0 (reference)

   TCC-TCT

28 (38)

72 (24)

2.1 (1.1–3.9)*

9 (41)

33 (26)

1.5 (0.5–4.0)

19 (37)

38 (23)

2.6 (1.2–5.8)*

   TCC-CCC

7 (10)

20 (7)

1.7 (0.6–4.6)

0 (0)

8 (6)

0.3 (0.0–5.6)d

7 (14)

12 (7)

2.9 (1.0–8.9)*

   TCC-CAC

13 (18)

73 (25)

0.9 (0.4–1.9)

2 (9)

29 (23)

0.3 (0.1–1.7)

11 (22)

44 (26)

1.3 (0.5–3.1)

Block2: TNF β 252, α-1031, -863, -857

   GTCC-GTCC

15 (18)

71 (21)

1.0 (reference)

9 (35)

30 (22)

1.0 (reference)

6 (10)

40 (21)

1.0 (reference)

   ATCT-XXXX e

35 (42)

101 (31)

1.7 (0.8–3.3)

13 (50)

41 (30)

1.0 (0.4–2.9)

22 (38)

59 (31)

2.5 (1.0–6.8)*

   ACCC-XXXX f

8 (9)

24 (7)

1.5 (0.6–4.2)

0 (0)

11 (8)

0.1 (0.0–2.6)d

8 (14)

13 (7)

4.1 (1.2–14.2)**

   Others

26 (31)

137 (41)

0.9 (0.4–1.8)

4 (15)

57 (41)

0.2 (0.1–0.7)*

22 (38)

80 (42)

1.9 (0.7–5.0)

Block3: all TNF 6 SNPs g

   GTCCGG* GTCCGG

10 (12)

57 (17)

1.0 (reference)

6 (23)

24 (17)

1.0 (reference)

4 (7)

32 (17)

1.0 (reference)

   ATCTGG-XXXXXX h

34 (40)

91 (27)

2.1 (0.9–4.7)

13 (50)

37 (26)

1.4 (0.5–4.3)

21 (36)

53 (27)

3.1 (1.0–10.0)*

   ACCCXX-XXXXXX i

8 (10)

24 (7)

1.8 (0.6–5.2)

0 (0)

11 (8)

0.2 (0.0–3.2)d

8 (14)

13 (7)

4.7 (1.2–18.2)*

   ACACGG-XXXXXX j

12 (14)

55 (16)

1.1 (0.5–2.9)

2 (8)

21 (15)

0.3 (0.1–2.0)

10 (17)

34 (17)

2.3 (0.7–8.2)

   Others

20 (24)

108 (33)

1.0 (0.4–2.4)

5 (19)

47 (34)

0.4 (0.1–1.6)

15 (26)

61 (32)

1.9 (0.6–6.3)

  1. * p < 0.05, ** p < 0.01
  2. a. Adjusted for age, sex, H. Pylori infection, CagA seropositivity, and smoking status (Never vs. Ever).
  3. b. Adjusted for age, sex, H. Pylori infection, and CagA seropositivity.
  4. c. If frequency of haplotype pairs among controls was less than 5%, we did not include in the logit model.
  5. d. Logit estimate for OR and 95% CI.
  6. e. Haplotype pairs were ATCT-GTCC, ATCC-ATCT, ATCT-ATCT and ATCT-ACAC.
  7. f. Haplotype pairs were ATCC-ACCC, ACCC-ACAC and ACCC-GTCC.
  8. g. All SNPs, TNF β 252, TNF α-1031, TNF α-863, TNF α-857, TNF α-238 and TNF α-308, were included to estimate individual haplotypes.
  9. h. Haplotype-pairs were ATCTGG-GTCCGG, ATCCGG-ATCTGG, ATCTGG-ATCTGG, ATCTGG-ACCCAG, ATCTGG-ACACGG and ATCTGG-ATCCAA.
  10. i. Haplotype-pairs were ACCCGG-ACACGG, ACCCAG-ACACGG, ACCCAC-GTCCGG, ACCCAC-GTCCGA and ATCCGG-ACCCAG.
  11. j. Haplotype-pairs were ACACGG-ACACGG, ACACGG-GTCCGG and ACACGG-GTCCGA.
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BMC Cancer

ISSN: 1471-2407

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