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Table 2 The association between genetic polymorphisms of TNF and risk of gastric cancer in a nested case-control study within the KMCC 19,688 enrolled cohort members.

From: The role of TNFgenetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study

    

OR (95% CI)a

 

Gene

Genotype

Case

Control

Co-dominant

Dominant

Additive

raw p valueb

TNF β 252 A/G (rs909253)

AA

23 (29)

83 (26)

1.0 (reference)

1.0 (reference)

1.0 (reference)

 
 

AG

43 (54)

170 (54)

0.9 (0.5–1.6)

0.9 (0.5–1.5)

0.9 (0.6–1.3)

0.5110

 

GG

13 (17)

61 (20)

0.8 (0.4–1.7)

 

0.8 (0.4–1.7)

 

TNF α-1031 T/C (rs1799964)

TT

55 (66)

205 (63)

1.0 (reference)

1.0 (reference)

1.0 (reference)

 
 

TC

25 (30)

109 (34)

0.8 (0.5–1.4)

0.8 (0.5–1.4)

0.9 (0.6–1.4)

0.5915

 

CC

3 (4)

10 (3)

1.1 (0.3–4.3)

 

0.9 (0.3–1.9)

 

TNF α-863 C/A (rs1800630)

CC

64 (77)

227 (70)

1.0 (reference)

1.0 (reference)

1.0 (reference)

 
 

CA

16 (19)

90 (28)

0.6 (0.3–1.1)

0.7 (0.4–1.2)

0.8 (0.5–1.3)

0.3416

 

AA

3 (4)

6 (2)

1.6 (0.4–6.9)

 

0.6 (0.2–1.7)

 

TNF α-857 C/T (rs1799724)

CC

49 (58)

227 (70)

1.0 (reference)

1.0 (reference)

1.0 (reference)

 
 

CT

33 (39)

92 (28)

1.7 (1.0–2.8)*

1.7 (1.0–2.8)*

1.6 (1.0–2.5)*

0.0466

 

TT

2 (3)

6 (2)

1.7 (0.3–9.2)

 

2.6 (1.0–6.4)*

 

TNF α-308 G/A (rs1800629) c

GG

75 (90)

288 (89)

1.0 (reference)

1.0 (reference)

1.0 (reference)

 
 

GA

8 (10)

34 (11)

0.8 (0.4–1.9)

0.8 (0.3–1.7)

0.7 (0.3–1.6)

0.4439

 

AA

-

-

-

 

0.5 (0.1–2.5)

 

TNF a-238 G/A (rs361525) c

GG

73 (88)

305 (92)

1.0 (reference)

1.0 (reference)

1.0 (reference)

 
 

GA

10 (12)

26 (8)

1.6 (0.7–3.6)

1.6 (0.7–3.6)

1.6 (0.7–3.6)

0.2333

 

AA

-

-

-

 

2.5 (0.5–12.1)

 
  1. * p < 0.05, ** p < 0.01
  2. a. Adjusted for age, sex, smoking status (Never vs. Ever), H. Pylori infection, and CagA seropositivity.
  3. b. Calculated by likelihood ratio test in each additive model. FDR adjusted p-values for all SNPs were not significant (p > 0.2).
  4. c. Excluded mutant genotype (AA genotype) frequency less than 1% or totally 0%.