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Table 1 Odds ratios and 95% CIs for gastric cancer risk according to basic characteristics of study subjects in a nested case-control study within the KMCC 19,688 enrolled cohort members.

From: The role of TNFgenetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study

 

Case

(N = 84)

Control

(N = 336)

OR (95% CI)

Sex

   

   Male

59 (70)

236 (70)

1.0 (reference)

   Female

25 (30)

100 (30)

1.0 (0.6–1.7)

Age a

   

   ≤ 63 years old

43 (51)

176 (52)

1.0 (reference)

   > 63 years old

41 (49)

160 (48)

1.1 (0.7–1.7)

Follow up b

   

   ≤ 6 years for FU

47 (56)

188 (56)

1.0 (reference)

   > 6 years for FU

37 (44)

148 (44)

1.0 (0.6–1.6)

Education level

   

   without any schooling

22 (26)

98 (29)

1.0 (reference)

   schooling

62 (74)

237 (71)

1.2 (0.7–2.0)

H. pylori infection

   

   negative (-)

12 (14)

48 (14)

1.0 (reference)

   positive (+)

72 (86)

288 (86)

1.0 (0.5–2.0)

CagA

   

   negative (-)

11 (13)

54 (16)

1.0 (reference)

   positive (+)

73 (87)

282 (84)

1.3 (0.6–2.5)

VacA

   

   negative (-)

36 (43)

156 (46)

1.0 (reference)

   positive (+)

48 (57)

180 (54)

1.2 (0.7–1.9)

Drink status c

   

   Never drinkers

38 (45)

144 (43)

1.0 (reference)

   Ever drinkers

46 (55)

188 (57)

0.9 (0.6–1.5)

Smoking status

   

   Never smokers

26 (31)

141 (42)

1.0 (reference)

   Ex smokers

21 (25)

82 (25)

1.4 (0.8–2.6)

   Current smokers

37 (44)

111 (33)

1.8 (1.0–3.2)*

Cigarette per day

   

   Never smokers

26 (31)

141 (42)

1.0 (reference)

   20 ≤

15 (18)

59 (18)

1.4 (0.7–2.8)

   >20

8 (9)

11 (3)

3.9 (1.4–10.7)**

   unreported

35 (42)

125 (37)

1.5 (0.9–2.7)

Smoking duration (years)

   

   Never smokers

26 (31)

141 (42)

1.0 (reference)

   20 ≤

5 (6)

29 (9)

0.9 (0.3–2.6)

   >20

32 (38)

88 (26)

1.9 (1.1–3.5)*

   unreported

21 (25)

78 (23)

1.5 (0.8–2.8)

Pack-Year d

   

   Never smokers

26 (31)

141 (42)

1.0 (reference)

   20<

5 (6)

14 (4)

1.9 (0.6–5.8)

   20–40

8 (10)

40 (12)

1.1 (0.5–2.6)

   ≥ 41

14 (17)

33 (10)

2.3 (1.1–4.9)*

   unreported

31 (36)

108 (32)

1.6 (0.9–2.8)

  1. * p < 0.05, ** p < 0.01
  2. a. Median age for cases and controls was 63 years. Age ranged from 40.0 to 83.0 years old.
  3. b. The median year for follow up was 6 years. Number of follow-up years ranged from 2 to 8 years.
  4. c. Ever drinkers defined as former and current drinkers.
  5. d. Pack years was calculated by the equation, (number of cigarettes smoked per day × number of years smoked)/20