Skip to main content

Advertisement

Table 4 Gene expression of MAP3K1, FGFR2, TNRC9 and LSP1 in human breast cancer cell lines according to their allelic loss status at the gene locus

From: Low-risk susceptibility alleles in 40 human breast cancer cell lines

Gene Genotype (Number of cell lines) Average expression level (Normalized Ct values)
MAP3K1 Het (n = 14) 24 ± 2
  Maj H no loss (n = 4) 24 ± 4
  Min H no loss (n = 2) 24 ± 0
  Maj H allelic loss (n = 1) 26
  Min H allelic loss (n = 6) 25 ± 1
FGFR2 Het (n = 7) 36 ± 5
  Maj H no loss (n = 4) 31 ± 7
  Min H no loss (n = 1) 33
  Maj H allelic loss (n = 6) 35 ± 6
  Min H allelic loss (n = 6) 38 ± 6
TNRC9 Het (n = 14) 30 ± 8
  Maj H no loss (n = 2) 24 ± 2
  Min H no loss (n = 3) 36 ± 8
  Maj H allelic loss (n = 1) 45
  Min H allelic loss (n = 7) 36 ± 9
LSP1 Het (n = 7) 37 ± 4
  Maj H no loss (n = 8) 37 ± 4
  Min H no loss (n = 2) 41 ± 5
  Maj H allelic loss (n = 3) 40 ± 5
  Min H allelic loss (n = 7) 38 ± 6
  1. Although numbers are small for some sample groups, there are no apparent differences in gene expression levels related to allelic loss status. Allelic loss data and qPCR expression data are detailed in Table 1 and Table 3, respectively. Maj H, major homozygotes; Min H, minor homozygotes; Het, heterozygote allele carriers.