Table 1 Relationship between s-MKRN1-Abs and the clinicopathological variables in 73 patients with esophageal SCC
From: Identification of Makorin 1 as a novel SEREX antigen of esophageal squamous cell carcinoma
| Â | Â | s-MKRN1-Abs | Â | |
|---|---|---|---|---|
| Â | Â | Positive | Negative | Â |
| Â | Â | (18 patients) | (55 patients) | Â |
Characteristics | Â | n (%) | n (%) | P value |
Age | Â | Â | Â | Â |
   Median | 65 yrs |  |  |  |
   Range | 39–86 yrs |  |  |  |
| Â | Under 59 yrs | 6 (33) | 21 (38) | Â |
| Â | Over 60 yrs | 12 (67) | 34 (62) | 0.711 |
Sex | Male | 16 (89) | 50 (91) | Â |
| Â | Female | 2 (11) | 5 (9) | 0.555 |
Location | Ce | 0 (0) | 4 (7) | Â |
| Â | Ut | 4 (22) | 7 (13) | Â |
| Â | Mt | 9 (50) | 29 (53) | Â |
| Â | Lt | 4 (22) | 9 (16) | Â |
| Â | Ae | 1 (6) | 4 (7) | Â |
| Â | Unknown | 0 (0) | 2 (4) | 0.682 |
Tumor size | Â | Â | Â | Â |
   Median | 58.6 mm |  |  |  |
   Range | 15–140 mm |  |  |  |
| Â | Under 29 mm | 2 (11) | 8 (15) | Â |
| Â | Over 30 mm | 13 (72) | 47 (85) | Â |
| Â | Unknown | 3 (17) | 0 (0) | 0.636 |
Histopathological Grading | GX | 8 (44) | 20 (37) | Â |
| Â | G1 | 6 (33) | 5 (9) | Â |
| Â | G2 | 4 (22) | 21 (38) | Â |
| Â | G3 | 0 (0) | 9 (16) | 0.008 |
Primary Tumor | Tis | 0 (0) | 1 (2) | Â |
| Â | T1 | 3 (17) | 16 (29) | Â |
| Â | T2 | 4 (22) | 10 (18) | Â |
| Â | T3 | 5 (28) | 13 (24) | Â |
| Â | T4 | 6 (33) | 15 (27) | 0.824 |
Regional Lymph Nodes | N0 | 3 (17) | 17 (31) | Â |
| Â | N1 | 15 (83) | 38 (69) | 0.194 |
Distant Metastasis | M0 | 16 (89) | 46 (84) | Â |
| Â | M1 | 2 (11) | 9 (16) | 0.455 |
Stage Grouping | Stage 0 | 0 (0) | 1 (2) | Â |
| Â | Stage I | 1 (6) | 12 (22) | Â |
| Â | Stage IIA | 1 (6) | 3 (5) | Â |
| Â | Stage IIB | 6 (33) | 11 (20) | Â |
| Â | Stage III | 8 (44) | 19 (35) | Â |
| Â | Stage IV | 2 (11) | 9 (16) | 0.552 |
Tumor Markers | Â | Â | Â | Â |
   SCC-Ag | Positive | 7 (39) | 19 (35) |  |
| Â | Negative | 11 (61) | 32 (58) | Â |
| Â | ND | 0 (0) | 4 (7) | 0.902 |
   CYFRA21-1 | Positive | 3 (17) | 13 (24) |  |
| Â | Negative | 15 (83) | 38 (69) | Â |
| Â | ND | 0 (0) | 4 (7) | 0.340 |
   CEA | Positive | 2 (11) | 12 (22) |  |
| Â | Negative | 16 (89) | 37 (67) | Â |
| Â | ND | 0 (0) | 6 (11) | 0.199 |