Table 1 Relationship between s-MKRN1-Abs and the clinicopathological variables in 73 patients with esophageal SCC
From: Identification of Makorin 1 as a novel SEREX antigen of esophageal squamous cell carcinoma
| s-MKRN1-Abs | ||||
|---|---|---|---|---|
| Positive | Negative | |||
| (18 patients) | (55 patients) | |||
| Characteristics | n (%) | n (%) | P value | |
| Age | ||||
| Median | 65 yrs | |||
| Range | 39–86 yrs | |||
| Under 59 yrs | 6 (33) | 21 (38) | ||
| Over 60 yrs | 12 (67) | 34 (62) | 0.711 | |
| Sex | Male | 16 (89) | 50 (91) | |
| Female | 2 (11) | 5 (9) | 0.555 | |
| Location | Ce | 0 (0) | 4 (7) | |
| Ut | 4 (22) | 7 (13) | ||
| Mt | 9 (50) | 29 (53) | ||
| Lt | 4 (22) | 9 (16) | ||
| Ae | 1 (6) | 4 (7) | ||
| Unknown | 0 (0) | 2 (4) | 0.682 | |
| Tumor size | ||||
| Median | 58.6 mm | |||
| Range | 15–140 mm | |||
| Under 29 mm | 2 (11) | 8 (15) | ||
| Over 30 mm | 13 (72) | 47 (85) | ||
| Unknown | 3 (17) | 0 (0) | 0.636 | |
| Histopathological Grading | GX | 8 (44) | 20 (37) | |
| G1 | 6 (33) | 5 (9) | ||
| G2 | 4 (22) | 21 (38) | ||
| G3 | 0 (0) | 9 (16) | 0.008 | |
| Primary Tumor | Tis | 0 (0) | 1 (2) | |
| T1 | 3 (17) | 16 (29) | ||
| T2 | 4 (22) | 10 (18) | ||
| T3 | 5 (28) | 13 (24) | ||
| T4 | 6 (33) | 15 (27) | 0.824 | |
| Regional Lymph Nodes | N0 | 3 (17) | 17 (31) | |
| N1 | 15 (83) | 38 (69) | 0.194 | |
| Distant Metastasis | M0 | 16 (89) | 46 (84) | |
| M1 | 2 (11) | 9 (16) | 0.455 | |
| Stage Grouping | Stage 0 | 0 (0) | 1 (2) | |
| Stage I | 1 (6) | 12 (22) | ||
| Stage IIA | 1 (6) | 3 (5) | ||
| Stage IIB | 6 (33) | 11 (20) | ||
| Stage III | 8 (44) | 19 (35) | ||
| Stage IV | 2 (11) | 9 (16) | 0.552 | |
| Tumor Markers | ||||
| SCC-Ag | Positive | 7 (39) | 19 (35) | |
| Negative | 11 (61) | 32 (58) | ||
| ND | 0 (0) | 4 (7) | 0.902 | |
| CYFRA21-1 | Positive | 3 (17) | 13 (24) | |
| Negative | 15 (83) | 38 (69) | ||
| ND | 0 (0) | 4 (7) | 0.340 | |
| CEA | Positive | 2 (11) | 12 (22) | |
| Negative | 16 (89) | 37 (67) | ||
| ND | 0 (0) | 6 (11) | 0.199 | |
