Figure 4

Simultaneous Foxp3 and IDO expression is associated with sentinel lymph node metastases in breast cancer. In order to demonstrate the combined immunosuppressive effect of Foxp3 and IDO, we categorized each subject into one of four groups based on whether positive or negative for Foxp3 and IDO. The median proportion of Foxp3⁺ and IDO⁺ cells in the SLN in cancer patients were used the cut-off points. Subjects who were positive both for Foxp3 and IDO were almost exclusively those with nodal disease, (p = 0.007).