TY - JOUR AU - Mansfield, Aaron S. AU - Heikkila, Paivi S. AU - Vaara, Ari T. AU - von Smitten, Karl AJ AU - Vakkila, Jukka M. AU - Leidenius, Marjut HK PY - 2009 DA - 2009/07/15 TI - Simultaneous Foxp3 and IDO expression is associated with sentinel lymph node metastases in breast cancer JO - BMC Cancer SP - 231 VL - 9 IS - 1 AB - There is evidence that the immune systems of patients with breast cancer are dysfunctional. Regulatory T cells (Tregs), and IDO, an immunosuppressive enzyme, are associated with more advanced disease in some cancers and may promote immunologic tolerance to tumors. Our aim was to assess whether expression of Foxp3, a marker of Tregs, and IDO were linked with nodal metastasis in breast cancer patients. Inhibitors of IDO are available and could potentially demonstrate utility in breast cancer if IDO drives progression of disease. SN - 1471-2407 UR - https://doi.org/10.1186/1471-2407-9-231 DO - 10.1186/1471-2407-9-231 ID - Mansfield2009 ER -