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Table 2 Univariate analysis of clinicopathological parameters influencing recurrence-free survival (RFS) and overall survival (OS).

From: Dual role of macrophage migration inhibitory factor (MIF) in human breast cancer

Variable

RFS

OS

 

na

events

p valued

n

events

p value

Clinicopathological factors:

      

Tumour sizeb

      

   pT1

46

10

 

48

8

 

   pT2

83

39

 

86

30

 

   pT3

11

5

< 0.001

12

3

0.001

   pT4

24

16

 

27

18

 

Lymph node statusb

      

   pN0

66

14

 

68

11

 

   pN1-3

97

53

< 0.001

101

44

< 0.001

Histological grade

      

   G1

18

4

 

19

5

 

   G2

69

23

 

74

18

 

   G3

78

43

< 0.001

80

37

0.003

Histological type

      

   invasive ductal

138

63

 

142

50

 

   invasive lobular

12

3

 

14

5

 

   other

15

4

0.167

17

5

0.876

Estrogen receptor status

      

   negative (IRSc 0–2)

46

24

 

46

19

 

   positive (IRS 3–12)

93

32

0.065

98

28

0.076

Progesterone receptor status

      

   negative (IRSc 0–2)

95

48

 

102

44

 

   positive (IRS 3–12)

50

13

0.010

50

8

< 0.001

MIF protein expression

      

   weak (IRSc 0–4)

51

26

 

57

27

 

   strong (IRS 5–12)

114

44

0.033

117

32

0.002

EGFR status

      

   negative (IRSc 0)

59

21

 

65

23

 

   positive (IRS 1–3)

91

44

0.146

93

35

0.867

  1. a Only female patients with primary, unilateral, invasive breast cancer were included. b According to the TNM classification of Sobin and Wittekind [38]. c IRS = immunoreactive score according to Remmele and Stegner [35]. d Fisher's exact test. Significant p values are marked in bold face.