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Table 2 Summary of analyses of RCC10 and 786-O cell lines.

From: Differences in regulation of tight junctions and cell morphology between VHL mutations from disease subtypes

Cell Line Subtype Epithelial Morphologya VHL Instability Aberrant ZO-1
   RCC10 786-O   
Wild-type - + + - -
control 1 - -   +++
del 114–178 1 - - +b ++
RC161/2QW 1 - - +b +++
S65W 1 - N/D + ++
N78S 1 - N/D + ++
L158P 1 - N/D + +++
L188Q 1 +/- + + +++
Y98H 2A + + - -
Y112H 2A + + - N/D
Y98N 2B + + +/- +
Y112N 2B + + - N/D
R167Q 2B + +/- + ++
R167W 2B + + +b N/D
V84L 2C + + N/D N/D
L188V 2C + + - -
  1. a – indicates a disorganized fibroblast-like morphology
  2.  +/- indicates that an intermediate morphology was observed
  3. b previously demonstrated in [53]
  4. N/D = not determined