Figure 3

Effect of Bcl-2 targeted therapy in combination with radiation therapy on the growth of human prostate cancer xenograft tumors. (A) In PC-3 Bcl-2 tumors, growth inhibition was present with antisense Bcl-2 oligonucleotide (ASO) alone or radiation alone. Combining ASO and radiation significantly inhibited of tumor growth compared to other treatment groups. (B) In PC-3-Neo tumors, similar results were evident with combinational therapy resulting in an additive effect with irradiation. mock no XRT, open circle; mock + XRT, X; ASO no XRT, open square; ASO + XRT, open diamond. (Adapted from Anai, 2007).