Figure 5

The expression of MMP-2, MMP-7, MMP-9 and MT1-MMP in gastric cancer cell lines AGS and NCI-N87 after treatment with DAC. (A) Real-time PCR analysis showed MMP-7 mRNA and MT1-MMP mRNA were downregulated in AGS after treatment with DAC. Data are expressed as mean ± SD, n = 3, *P < 0.001, vs DAC(-). (B) Real-time PCR analysis showed MMP-7 mRNA and MT1-MMP mRNA were downregulated in NCI-N87 after treatment with DAC. Data are expressed as mean ± SD, n = 3, *P < 0.001, vs DAC(-). (C) Weatern blotting analysis showed MMP-7 protein and MT1-MMP protein were downregulated in AGS and NCI-N87 after treatment with DAC.