Table 2 Demographic/clinicopathological parameters in relation to WIF1 and DKK3 promoter methylation
WIF1 methylation | DKK3 methylation | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Variable | Categorization | n1 | No (%) | Yes (%) | P 2 | n1 | No (%) | Yes (%) | P 2 |
Clinicopathological factors | |||||||||
Age at diagnosis | |||||||||
<57 years | 74 | 32 (43) | 42 (57) | 0.127 | 74 | 37 (50) | 37 (50) | 0.007 | |
≥ 57 years | 76 | 23 (30) | 53 (70) | 76 | 21 (28) | 55 (72) | |||
Tumor size3 | |||||||||
pT1-pT2 | 129 | 48 (37) | 81 (63) | 1.000 | 129 | 52 (40) | 77 (60) | 0.440 | |
pT3-pT4 | 18 | 7 (39) | 11 (61) | 18 | 5 (28) | 13 (72) | |||
Lymph node status3 | |||||||||
pN0 | 72 | 29 (40) | 43 (60) | 0.606 | 72 | 32 (44) | 40 (56) | 0.170 | |
pN1-pN3 | 71 | 25 (35) | 46 (65) | 71 | 23 (32) | 48 (67) | |||
Histological grade | |||||||||
G1-G2 | 88 | 28 (32) | 60 (68) | 0.170 | 88 | 31 (35) | 57 (65) | 0.313 | |
G3 | 62 | 27 (44) | 35 (57) | 62 | 27 (44) | 35 (57) | |||
Histological type | |||||||||
IDC | 122 | 43 (35) | 79 (65) | 122 | 45 (37) | 77 (63) | |||
lobular | 19 | 7 (37) | 12 (63) | 0.296 | 19 | 7 (37) | 12 (63) | 0.236 | |
other | 9 | 5 (56) | 4 (44) | 9 | 6 (67) | 3 (33) | |||
Immunohistochemistry | |||||||||
Estrogen receptor | |||||||||
negative (IRS4 0–2) | 47 | 21 (45) | 26 (55) | 0.142 | 47 | 20 (43) | 27 (57) | 0.467 | |
positive (IRS 3–12) | 98 | 31 (32) | 67 (68) | 98 | 35 (36) | 63 (64) | |||
Progesterone receptor | |||||||||
negative (IRS4 0–2) | 51 | 22 (43) | 29 (57) | 0.206 | 51 | 21 (41) | 30 (59) | 0.593 | |
positive (IRS 3–12) | 94 | 30 (32) | 64 (68) | 94 | 34 (36) | 60 (64) | |||
WIF1 promoter | |||||||||
unmethylated | - | - | - | - | 55 | 29 (53) | 26 (47) | 0.009 | |
methylated | - | - | - | 95 | 29 (31) | 66 (69) | |||