Figure 4

Distribution of WIF1 and DKK3 promoter methylation in primary breast carcinomas. Methylation status of either gene has been determined by MSP in the same tumors. Of n = 150 breast cancer patients, the larger fraction reveals an identical methylation status of both genes (63.3%). In the remaining smaller fraction (36.6%), methylation of only one of the two genes could be detected. In total, WIF1 methylation was significantly associated with DKK3 methylation (p = 0.009; Fisher's exact test).