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Table 2 Prostasin mRNA levels in normal and affected tissues.

From: Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis

Variable mRNA level in normal tissue Mean (SD) Pa mRNA level in adenomas/carcinomas Mean (SD)    Pa Pb
Prostasin        
   Healthy individuals 0.96 (0.29)       
   Mild/moderate 1.10 (0.38) NS 0.62 (0.24)    NS <0.001
   Severe 1.08 (0.46) NS 0.73 (0.50)    NS <0.01
   Carcinoma distant adjacent 0.85 (0.65) NS 0.61 (0.60)    NS <0.05
  0.90 (0.76) NS      <0.01
   All adenomas and carcinomas 0.96 (0.61) NS 0.62 (0.48)    <0.05 ND
PN-1        
   Healthy individual 0.022 (0.030)       
   Mild/moderate 0.015 (0.017) NS 0.041 (0.028)    NS <0.001
   Severe 0.010 (0.003) NS 0.033 (0.031)    NS <0.05
   Carcinoma distant adjacent 0.028 (0.027) NS 0.063 (0.060)    <0.001 <0.001
  0.025 (0.018) NS      <0.001
  1. The mRNA levels were normalised to β-actin mRNA levels.
  2. NS = not significant
  3. ND = not determined
  4. p value for the comparison to the expression levels in healthy individuals using a one-way ANOVA and Tukey's post test for paired comparisons.
  5. a) p value for the comparison to the expression levels in healthy individuals using a one-way ANOVA and Tukey's post test for paired comparisons.
  6. b) p value for the comparison of the expression levels in normal and affected tissue from the same individual using a paired t-test