Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis

BMC Cancer

Table 2 Prostasin mRNA levels in normal and affected tissues.

Variable	mRNA level in normal tissue Mean (SD)	P^a	mRNA level in adenomas/carcinomas Mean (SD)	P^a	P^b
Prostasin
Healthy individuals	0.96 (0.29)
Mild/moderate	1.10 (0.38)	NS	0.62 (0.24)	NS	<0.001
Severe	1.08 (0.46)	NS	0.73 (0.50)	NS	<0.01
Carcinoma distant adjacent	0.85 (0.65)	NS	0.61 (0.60)	NS	<0.05
	0.90 (0.76)	NS			<0.01
All adenomas and carcinomas	0.96 (0.61)	NS	0.62 (0.48)	<0.05	ND
PN-1
Healthy individual	0.022 (0.030)
Mild/moderate	0.015 (0.017)	NS	0.041 (0.028)	NS	<0.001
Severe	0.010 (0.003)	NS	0.033 (0.031)	NS	<0.05
Carcinoma distant adjacent	0.028 (0.027)	NS	0.063 (0.060)	<0.001	<0.001
	0.025 (0.018)	NS			<0.001

The mRNA levels were normalised to β-actin mRNA levels.
NS = not significant
ND = not determined
p value for the comparison to the expression levels in healthy individuals using a one-way ANOVA and Tukey's post test for paired comparisons.
a) p value for the comparison to the expression levels in healthy individuals using a one-way ANOVA and Tukey's post test for paired comparisons.
b) p value for the comparison of the expression levels in normal and affected tissue from the same individual using a paired t-test

ISSN: 1471-2407