Correlation between MMPs and their inhibitors in breast cancer tumor tissue specimens and in cell lines with different metastatic potential

Table 1 General characteristics of previously described human breast cancer cell lines

Cell Line	Histopathologycal type	Origin	ER	PR	Invasive potential	Metastatic potencial
MCF-7	Invasive ductal carcinoma	Metastasis (pleural effusion)	+	+	+	--
ZR-75-1	Invasive ductal carcinoma	Metastasis (ascite)	+	+	++	--
MDA-MB-435	Invasive ductal carcinoma	Metastasis (pleural effusion)	-	-	+++	++++
MDA-MB-231	Invasive ductal carcinoma	Metastasis (pleural effusion)	-	-	++++	+
Hs578T	Carcinosarcoma	Tumor primary	-	-	++++	++++

Table based on previously published data [39–41].
ER: status of estrogen receptor; PR: status of progesterone receptor (Negative (-), Positive (+)).
^aInvasive potential analyzed by chemoinvasion assays through of reconstituted basal lamina (Matrigel) in transwell plates.
^bMetastatic potential verified through of spontaneous metastasis assays in immune deficient mice

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