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Table 1 P-gp, MRP, BCRP expression and activity in K562, HL60 and their variant cell

From: P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients

  Expression Activity
  P-gp MRP1 BCRP P-gp MRP BCRP
  UIC2 MRPm6 BXP21 DiOC2 (3)/zosuquidar C-AM/MK571 Mitox/FTC
HL60 1.14 ± 0.27 1.2 ± 0.19 1.54 ± 0.79 0 0.09 ± 0.08 0
HL60/DNR 19.30 ± 4.79 0.91 ± 0.52 1.47 ± 0.61 0.98 ± 0.004 0.09 ± 0.04 0
HL60/ADR 1.50 ± 0.44 3.15 ± 0.07 1.56 ± 0.77 0 0.91 ± 0.04 0.17 ± 0.13
K562 0.98 ± 0.17 1.35 ± 0.37 1.25 ± 1.04 0 0.03 ± 0.06 0.043 ± 0.06
K562/HHT40 2.48 ± 0.60 1.53 ± 0.52 1.52 ± 0.51 0.41 ± 0.01 0.17 ± 0.05 0.13 ± 0.14
K562/HHT90 3.24 ± 0.80 1.2 ± 009 1.65 ± 0.64 0.83 ± 0.05 0.22 ± 0.14 0.05 ± 0.07
K562/Dox 11.58 ± 3.42 1.43 ± 0.37 1.85 ± 0.46 0.99 ± 0.01 0.13 ± 0.09 0
K562/BCRP 1.17 ± 0.2 1.13 ± 0.30 7.57 ± 0.54 0 0 0.59 ± 0.11