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Table 1 P-gp, MRP, BCRP expression and activity in K562, HL60 and their variant cell

From: P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients

 

Expression

Activity

 

P-gp

MRP1

BCRP

P-gp

MRP

BCRP

 

UIC2

MRPm6

BXP21

DiOC2 (3)/zosuquidar

C-AM/MK571

Mitox/FTC

HL60

1.14 ± 0.27

1.2 ± 0.19

1.54 ± 0.79

0

0.09 ± 0.08

0

HL60/DNR

19.30 ± 4.79

0.91 ± 0.52

1.47 ± 0.61

0.98 ± 0.004

0.09 ± 0.04

0

HL60/ADR

1.50 ± 0.44

3.15 ± 0.07

1.56 ± 0.77

0

0.91 ± 0.04

0.17 ± 0.13

K562

0.98 ± 0.17

1.35 ± 0.37

1.25 ± 1.04

0

0.03 ± 0.06

0.043 ± 0.06

K562/HHT40

2.48 ± 0.60

1.53 ± 0.52

1.52 ± 0.51

0.41 ± 0.01

0.17 ± 0.05

0.13 ± 0.14

K562/HHT90

3.24 ± 0.80

1.2 ± 009

1.65 ± 0.64

0.83 ± 0.05

0.22 ± 0.14

0.05 ± 0.07

K562/Dox

11.58 ± 3.42

1.43 ± 0.37

1.85 ± 0.46

0.99 ± 0.01

0.13 ± 0.09

0

K562/BCRP

1.17 ± 0.2

1.13 ± 0.30

7.57 ± 0.54

0

0

0.59 ± 0.11