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Figure 3 | BMC Cancer

Figure 3

From: P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients

Figure 3

Apoptosis induced by DM4 and AVE9633 in the presence or absence of MRP inhibitor MK571 in HL60 an HL60/ADR cells. HL60 (grey) and HL60/ADR (black) cells were treated with DM4 or AVE9633 at 40 nM in the presence or absence of MK571 (5 μM) for 48 h, then stained with Annexin V/propidium iodide for flow cytometry. All experiments were done in triplicate.

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