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Table 2 Summary of genetic studies examining Ets factor functions in tumorigenesis

From: The Ets dominant repressor En/Erm enhances intestinal epithelial tumorigenesis in ApcMin mice

Ets Genetic manipulation Tissue Tumor model Effect on tumorigenesis Subcompartment with effect Reference
PEA3 subfamily Dominant negative Mammary gland MMTV-Neu Inhibition (increased latency; decreased number and size) Epithelium [7]
Ets2 Hypomorphic mutant Mammary gland MMTV-PyMT
MMTV-Neu
Inhibition (increased latency; decreased number and size) Stroma [6, 8]
Ets2 One extra gene copy Intestine ApcMin Inhibition (decreased number) Not determined [18]
Ets family Dominant repressor Intestine ApcMin Promotion
(increased number)
Epithelium This paper