Table 2 Summary of genetic studies examining Ets factor functions in tumorigenesis
From: The Ets dominant repressor En/Erm enhances intestinal epithelial tumorigenesis in ApcMin mice
Ets | Genetic manipulation | Tissue | Tumor model | Effect on tumorigenesis | Subcompartment with effect | Reference |
|---|---|---|---|---|---|---|
PEA3 subfamily | Dominant negative | Mammary gland | MMTV-Neu | Inhibition (increased latency; decreased number and size) | Epithelium | [7] |
Ets2 | Hypomorphic mutant | Mammary gland | MMTV-PyMT MMTV-Neu | Inhibition (increased latency; decreased number and size) | Stroma | |
Ets2 | One extra gene copy | Intestine | ApcMin | Inhibition (decreased number) | Not determined | [18] |
Ets family | Dominant repressor | Intestine | ApcMin | Promotion (increased number) | Epithelium | This paper |