Figure 1

Projection of the seven kinesin inhibitors onto the Volsurf global BBB model. The blue circles at the left of the red line are those compounds belonging to the model and experimentally determined as BBB negative (non permeable) and the red circles above the blue line are those compounds which have been experimentally determined as BBB positive (permeable). Compounds projected within the area included between the red and the blue line (the uncertainty area) show a certain level of uncertainty and their BBB penetrating capacity should be cross validated using an additional model system.