Colorectal carcinomas in MUTYH-associated polyposis display histopathological similarities to microsatellite unstable carcinomas

Table 3 Concise overview of data in Table 2

	MAP	Sporadic CRC	Sporadic MSI-high	Lynch (based on MMR mutations)
Average age (years)	49	68	67–75	47
MAC stage C or D	+	++	++	+
Proximal location	++	+	+++	++
(Meta) synchronous CRC	+	0	ND	+
Poor Differentiation	+	0	+	+
Mucinous (>50%)	+ *	+ *	+	+
Crohn's like infiltrate (conspicuous)	+	+	++	+
Necrosis	+	++	+	ND
*TILs present**	++	+	++	+
TILs marked	+	0	+	+
*APC* -MCR mutations	+	++	+	+
*KRAS* mutations (codon 12/13)	++	+	+	+
Beta-catenin (nuclear staining)	+	+++	+	++
Beta-catenin ( *CTNNB1)* mutations	0	0	0	+
P53 (nuclear staining >25%)	+	++	+	+++
*P53* mutations	++	++	+	+
*SMAD4* mutations	+	+	0	+
MSI-high	0	+	+++	+++

0 = 0–10%, + = 11–40%, ++ = 41–70%, +++ = >70% ND = no data
* mucinous rate in MAP CRCs in this study was two times more than in sporadic CRCs: 23% and 12% respectively (see also table 2).

ISSN: 1471-2407