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Table 3 Concise overview of data in Table 2

From: Colorectal carcinomas in MUTYH-associated polyposis display histopathological similarities to microsatellite unstable carcinomas

  MAP Sporadic CRC Sporadic MSI-high Lynch (based on MMR mutations)
Average age (years) 49 68 67–75 47
MAC stage C or D + ++ ++ +
Proximal location ++ + +++ ++
(Meta) synchronous CRC + 0 ND +
Poor Differentiation + 0 + +
Mucinous (>50%) + * + * + +
Crohn's like infiltrate (conspicuous) + + ++ +
Necrosis + ++ + ND
TILs* present ++ + ++ +
TILs marked + 0 + +
APC -MCR mutations + ++ + +
KRAS mutations (codon 12/13) ++ + + +
Beta-catenin (nuclear staining) + +++ + ++
Beta-catenin ( CTNNB1) mutations 0 0 0 +
P53 (nuclear staining >25%) + ++ + +++
P53 mutations ++ ++ + +
SMAD4 mutations + + 0 +
MSI-high 0 + +++ +++
  1. 0 = 0–10%, + = 11–40%, ++ = 41–70%, +++ = >70% ND = no data
  2. * mucinous rate in MAP CRCs in this study was two times more than in sporadic CRCs: 23% and 12% respectively (see also table 2).