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Table 2 Histological and molecular features of carcinomas

From: Colorectal carcinomas in MUTYH-associated polyposis display histopathological similarities to microsatellite unstable carcinomas

Characteristics
Colon carcinomas
  MAP Sporadic CRC Sporadic MSI-high Lynch (based on MMR mutations)
Average age at CRC   49 years [CS]
59 years11
68 years 67–75 years 47 years
TNM stage III or IV 34% (51/148)
55% (10/18)[1]
42% (1781/4193) 43% (19/44) 15% (15/101)
Proximal location   69% (35/51) [CS]
29% (7/24)11
43% (16/37)4
46% (6/13)31
23% (1887/8129) 75% (308/411) 67% (74/111)
(Meta) synchronous CRC   23% (10/44) [CS]
33% (6/18)11
26% (8/29)4
2% (14/832)   18% (7/38)
Poor Differentiation   26% (11/42) [CS]
22% (5/23)11
100% (16/16)31
10% (765/7590) 41% (203/501) 38% (38/101)
Mucinous (>50%) 21% (9/42) [CS]
13% (3/23)11
0% (0/16)31
12% (292/2480) 28% (104/376) 35% (40/113)
Crohn's like
infiltrate
Conspicuous 33% (13/40) [CS]
31% (5/16)31
28% (586/2059) 54% (318/589) 49% (37/76)
Necrosis   40% (16/40) [CS] 77% (356/465) 17% (9/52)  
TILs* Present (moderate and marked) 74% (31/42) [CS]
50% (8/16)31
24% (338/1406) 58% (155/268) 33% (4/12)
  Marked 17% (7/42) [CS] 4% (34/889) 29% (63/218) 17% (2/12)
APC Mutations ( MCR, also outside the MCR) 14% (5/36) [CS]†
43% (6/14)11‡
83% (5/6)31†
63% (459/724) *
52% (281/539)
5% (1/21)
41% (56/136)
33%(6/18)
KRAS Mutations codon 12/13 64% (23/36) [CS]
64% (9/14)11
29% (1090/3710) 20% (56/280) 34% (91/267)
Beta-catenin ( CTNNB1 ) Nuclear staining 11% (4/35) [CS]
71% (12/17)11
77% (138/179) 13% (4/31) 59% (40/68)
  Mutations 0% (0/16)5 5% (30/610) 7% (2/27) 20% (11/56)
P53 Nuclear staining
>25%
34% (12/35) [CS]
53% (8/15)11
57% (668/1167) 15% (20/130) 72% (23/32)
  Mutations 60% (9/15) [CS]
21% (3/14)11
43% (1808/4299) 22% (21/95) 22% (2/9)
SMAD4 Mutations 26% (5/19) [CS]
0% (0/14)11
22% (17/77)   18% (2/11)
MSI High 0% (0/33) [CS]
0% (0/17)11
18% (2/11)31
33% (1/3)43
12% (227/1834)   90% (88/98)
  1. CS = current study, MAP = MUTYH-associated polyposis, MSS= microsatellite stable, MSI = microsatellite instability, TIL = Tumour Infiltrating Lymphocytes, MCR = mutation cluster region. *Relative large proportion of missense mutations (29%) in study by Luchtenborg et al as compared to other studies, explaining the high overall percentage of APC mutations in the MCR only group. See Additional file 1 online for more details and article references.