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Table 2 Marker expression and mammographic density by ethnicity

From: Mammographic density and epithelial histopathologic markers

Marker   All women (n = 159) Caucasian (n = 49) Japanese (n = 70)
   Category*   Category   Category  
   1 2 P-value 1 2 P-value 1 2 P-value
ERα % density 36.9 35.6 0.75 39.8 23.9 0.04 38.8 44.5 0.39
  Dense area# 33.7 33.6 0.98 38.2 26.2 0.18 33.8 38.0 0.50
  Number 122 35   38 11   53 16  
ERβ % density 35.8 38.2 0.49 33.8 45.4 0.05 40.2 39.1 0.85
  Dense area 33.0 34.6 0.66 34.4 40.9 0.38 35.2 33.3 0.74
  Number 110 47   36 13   47 21  
PR % density 34.9 38.3 0.28 35.3 41.0 0.30 37.5 41.0 0.57
  Dense area 30.6 36.4 0.09 31.1 45.9 0.03 35.2 34.4 0.90
  Number 77 81   23 25   35 35  
HER2/neu % density 37.1 36.3 0.82 35.7 40.9 0.38 41.3 37.9 0.57
  Dense area 34.4 33.2 0.74 36.4 36.5 0.99 35.5 33.6 0.73
  Number 104 52   34 15   45 23  
Ki-67 % density 34.3 37.7 0.32 35.5 39.3 0.53 36.8 41.2 0.46
  Dense area 32.9 33.5 0.87 38.7 34.9 0.60 32.8 35.3 0.66
  Number 65 90   16 32   31 39  
PCNA % density 36.0 38.2 0.50 37.7 37.1 0.91 38.7 42.2 0.52
  Dense area 33.4 33.7 0.94 36.7 36.4 0.97 35.1 33.9 0.82
  Number 95 63   28 20   42 28  
  1. * Categories for ERα, ERβ, HER2/neu and PCNA; category 1 <10% staining, category 2 ≥ 10% staining. Categories for PR and Ki-67; category 1 = no staining, category 2 = any staining
  2. Mean percent breast density
  3. # Mean dense area in cm2
  4. Mean values and p-values calculated using general linear models adjusted for age at mammogram, BMI, ethnicity, HT use at mammogram, menopausal status, parity, age at first live birth, age at menarche and family history of breast cancer.
  5. (ERα = estrogen receptor alpha; ERβ = estrogen receptor beta; PR = progesterone receptor; HER2/neu = Human Epidermal growth factor receptor2; PCNA = Proliferating Cell Nuclear Antigen; BMI = body mass index)