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Table 5 Estimated haplotypes using the WHAP program and SNPs with a frequency greater than 5% for cases and controls combined.

From: Variations in the NBN/NBS1 gene and the risk of breast cancer in non-BRCA1/2French Canadian families with high risk of breast cancer

   Estimated Haplotype Frequencies   
Haplotype SNPs1
10-1-5-11-16-17-18-19-8-20-9-21
Cases Controls Combined p-value2 OR (95%CI)
WH1 TGGTGCCCTAAA 0.511 0.558 0.538 0.361 REF
WH2 TACTATAACGGT 0.250 0.293 0.264 0.399 0.9 (0.6–1.6)
WH3 TGGCGCCCTAAA 0.065 0.096 0.080 0.277 0.7 (0.3–1.7)
WH4 AGGTGCCCTAAA 0.087 0.030 0.059 0.0227 3.2 (1.1–9.2)
WH5 TGGTGCCCCAAA 0.038 0.008 0.027 0.0883 5.1 (0.9–30.1)
WH6 TAGTATAACGGT 0.033 0.007 0.021 0.176 7.8 (0.8–30.5)
WH7 TGCTGCCCTAAA 0.017 0.008 0.011 0.542 2.4 (0.3–16.1)
  1. 1SNPs identification as in Table 2 and 3.2p-value for haplotype-specific test, each haplotype versus all other haplotypes.