Variations in the NBN/NBS1 gene and the risk of breast cancer in non-BRCA1/2French Canadian families with high risk of breast cancer

Table 5 Estimated haplotypes using the WHAP program and SNPs with a frequency greater than 5% for cases and controls combined.

		Estimated Haplotype Frequencies
Haplotype	SNPs¹ 10-1-5-11-16-17-18-19-8-20-9-21	Cases	Controls	Combined	p-value²	OR (95%CI)
WH1	TGGTGCCCTAAA	0.511	0.558	0.538	0.361	REF
WH2	TACTATAACGGT	0.250	0.293	0.264	0.399	0.9 (0.6–1.6)
WH3	TGGCGCCCTAAA	0.065	0.096	0.080	0.277	0.7 (0.3–1.7)
WH4	AGGTGCCCTAAA	0.087	0.030	0.059	0.0227	3.2 (1.1–9.2)
WH5	TGGTGCCCCAAA	0.038	0.008	0.027	0.0883	5.1 (0.9–30.1)
WH6	TAGTATAACGGT	0.033	0.007	0.021	0.176	7.8 (0.8–30.5)
WH7	TGCTGCCCTAAA	0.017	0.008	0.011	0.542	2.4 (0.3–16.1)

¹SNPs identification as in Table 2 and 3.²p-value for haplotype-specific test, each haplotype versus all other haplotypes.

ISSN: 1471-2407