Figure 2

In silico analysis of the effect of coding variants on putative exonic splicing enhancer (ESE) motifs by the ESEfinder program. Only scores for predicted motifs potentially abolished by exonic variants are shown. Light gray: motif matrix scores for consensus sequences. Dark gray: motif matrix scores for variant sequences. The name of the SR protein potentially involved is indicated for each score pair. Doted line indicates the default threshold used by ESEfinder for the corresponding motif.