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Table 2 Association of BNIP3 mRNA and protein expression with clinicopathological features in invasive breast cancer (n = 40).

From: Expression of BNIP3 in invasive breast cancer: correlations with the hypoxic response and clinicopathological features

  BNIP3 mRNA   BNIP3 protein  
Feature* Low High p-value Low High p-value
Lymph node status       
   Negative 5 12 0.001 3 14 0.009
   Positive 19 4   15 9  
MAI (2 mm 2 )       
   1–12 9 9 0.335 4 14 0.027
   ≥ 13 15 7   13 9  
ER       
   Negative 7 6 0.733 5 8 1.000
   Positive 17 10   12 15  
PR       
   Negative 12 7 0.755 10 9 0.337
   Positive 12 9   7 14  
Tumor size       
   0–2 cm 7 6 0.733 3 10 0.103
   > 2 cm 17 10   14 13  
Histological grade       
   I/II 11 10 0.349 6 15 0.108
   III 13 6   12 8  
Necrosis       
   Negative 17 9 0.500 10 16 0.520
   Positive 7 7   7 7  
  1. * MAI: mitotic activity index, ER: estrogen receptor, PR: progesterone receptor.