Figure 1

Effect of staurosporine on the A549 cell morphology. A: A549 cells in the control group. Cells were short, spindle-shaped and triangle-shaped and resembled epithelial cells (200 ×). B: A549 cells treated with 1 nmol/L staurosporine for 24 h. Some of the cells were long spindle-shaped and exhibit slender protrusions (arrows). Small cavities were visible in the cytoplasm of some cells (arrow heads) (200 ×). C: A549 cells treated with 10 nmol/L staurosporine for 24 h. Some A549 cells retracted and became gradually round-shaped (arrows) (200 ×). D: A549 cells treated with 100 nmol/L staurosporine for 24 h. Some A549 cells retracted, became gradually round-shaped, and shed off (arrows) (200 ×).