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Table 3 Haplotypes for the SNPs in the FGFR2 and FGFR4 genes and skin cancer risk

From: Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study

FGFR2    Melanoma SCC BCC
     Controls Cases Cases Cases
A B C D n % n % n % n %
0 0 0 0 779 56.4 166 55.3 286 59.8 270 55.1
     Multivariate OR 1.00 1.00 1.00
1 1 1 1 532 38.5 118 39.3 177 37.0 196 40.0
     Multivariate OR 1.06 (0.82–1.38) 0.90 (0.72–1.11) 1.06 (0.85–1.32)
1 1 0 0 25 1.8 3 1.0 8 1.7 8 1.6
     Multivariate OR 0.55 (0.16–1.89) 0.89 (0.39–2.00) 0.90 (0.40–2.05)
1 1 1 0 17 1.2 8 2.7 3 0.6 6 1.2
     Multivariate OR 2.42 (1.00–5.87) 0.46 (0.13–1.60) 1.03 (0.40–2.69)
Rare < 1% 29 2.1 5 1.7 4 0.8 10 2.1
     Multivariate OR 0.80 (0.31–2.06) 0.41 (0.15–1.13) 0.98 (0.50–1.93)
A: rs11200014; B: rs2981579; C: rs1219648; D: rs2420946
  FGFR4    Melanoma SCC BCC
     Controls Cases Cases Cases
  A B C n % n % n % n %
  0 0 1 446 29.7 118 30.7 121 25.8 164 32.2
     Multivariate OR 1.00 1.00 1.00
  0 0 0 391 26.0 89 23.2 130 27.7 133 26.1
     Multivariate OR 0.86 (0.63–1.17) 1.22 (0.92–1.62) 0.93 (0.71–1.21)
  0 1 0 343 22.8 83 21.7 113 24.0 106 20.9
     Multivariate OR 0.91 (0.66–1.26) 1.21 (0.90–1.64) 0.82 (0.62–1.10)
  1 0 0 293 19.5 84 22.0 95 20.3 95 18.8
     Multivariate OR 1.08 (0.78–1.49) 1.19 (0.88–1.62) 0.88 (0.66–1.18)
  Rare < 1% 30 2.0 9 2.4 10 2.2 10 1.9
     Multivariate OR 1.21 (0.49–2.96) 1.31 (0.55–3.10) 0.89 (0.37–2.16)
A: rs1966265*; B: rs376618; C: rs351855
  1. 0, common allele; 1, rare allele.
  2. Logistic regression adjusted for age.
  3. p-values for global tests are >0.05.
  4. *The SNP rs1966265 failed the assay and the rs12519145 was genotyped instead (r2 = 0.8).