Table 3 Haplotypes for the SNPs in the FGFR2 and FGFR4 genes and skin cancer risk

0

0

0

0

779

56.4

166

55.3

286

59.8

270

55.1

Multivariate OR

1.00

1.00

1.00

1

1

1

1

532

38.5

118

39.3

177

37.0

196

40.0

Multivariate OR

1.06 (0.82–1.38)

0.90 (0.72–1.11)

1.06 (0.85–1.32)

1

1

0

0

25

1.8

3

1.0

8

1.7

8

1.6

Multivariate OR

0.55 (0.16–1.89)

0.89 (0.39–2.00)

0.90 (0.40–2.05)

1

1

1

0

17

1.2

8

2.7

3

0.6

6

1.2

Multivariate OR

2.42 (1.00–5.87)

0.46 (0.13–1.60)

1.03 (0.40–2.69)

Rare < 1%

29

2.1

5

1.7

4

0.8

10

2.1

Multivariate OR

0.80 (0.31–2.06)

0.41 (0.15–1.13)

0.98 (0.50–1.93)

FGFR4

Melanoma

SCC

BCC

Controls

Cases

Cases

Cases

A

B

C

n

%

n

%

n

%

n

%

0

0

1

446

29.7

118

30.7

121

25.8

164

32.2

Multivariate OR

1.00

1.00

1.00

0

0

0

391

26.0

89

23.2

130

27.7

133

26.1

Multivariate OR

0.86 (0.63–1.17)

1.22 (0.92–1.62)

0.93 (0.71–1.21)

0

1

0

343

22.8

83

21.7

113

24.0

106

20.9

Multivariate OR

0.91 (0.66–1.26)

1.21 (0.90–1.64)

0.82 (0.62–1.10)

1

0

0

293

19.5

84

22.0

95

20.3

95

18.8

Multivariate OR

1.08 (0.78–1.49)

1.19 (0.88–1.62)

0.88 (0.66–1.18)

Rare < 1%

30

2.0

9

2.4

10

2.2

10

1.9

Multivariate OR

1.21 (0.49–2.96)

1.31 (0.55–3.10)

0.89 (0.37–2.16)