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Table 2 NFKBIA and NFKBIB Polymorphisms and Adjusted Risk of Epithelial Ovarian Cancer

From: Polymorphisms in NF-κB Inhibitors and Risk of Epithelial Ovarian Cancer

     General Model OR (95%CI) Ordinal Model OR (95% CI)
Gene SNP ID bp to next MAF AB v AA BB v AA p-value per-allele p-value
NFKBIA rs3138055 639 0.28 0.99 (0.81–1.20) 1.02 (0.72–1.46) 0.98 1.00 (0.87–1.16) 0.99
  rs696 124 0.38 0.94 (0.77–1.15) 0.85 (0.64–1.14) 0.54 0.93 (0.81–1.06) 0.28
  rs8904 190 0.38 0.93 (0.76–1.13) 0.84 (0.63–1.13) 0.49 0.92 (0.80–1.05) 0.24
  rs1022714 900 0.21 0.94 (0.78–1.15) 0.98 (0.61–1.59) 0.85 0.96 (0.82–1.13) 0.65
  rs3138054 485 0.17 1.18 (0.97–1.44) 0.97 (0.51–1.85) 0.26 1.13 (0.94–1.35) 0.19
  rs2233415 978 0.27 0.84 (0.69–1.02) 0.93 (0.65–1.32) 0.22 0.91 (0.78–1.05) 0.20
  rs1957106 500 0.30 0.77 (0.63–0.94) 0.92 (0.65–1.30) 0.03 0.87 (0.76–1.01) 0.07
  rs2233409 253 0.23 1.11 (0.92–1.35) 0.93 (0.61–1.40) 0.48 1.04 (0.89–1.21) 0.61
  rs2233407 331 0.06 1.27 (0.96–1.70) 0.24 (0.04–1.24) 0.06 1.13 (0.86–1.47) 0.38
  rs3138053 515 0.29 1.03 (0.85–1.25) 1.06 (0.75–1.49) 0.93 1.03 (0.89–1.19) 0.70
  rs3138050 2,352 0.22 1.04 (0.77–1.40) 2.28 (1.10–4.73) 0.09 1.20 (0.94–1.54) 0.14
  rs3138045 5,214 0.22 1.00 (0.82–1.22) 1.25 (0.80–1.97) 0.62 1.05 (0.89–1.23) 0.56
  rs2007960 --- 0.39 1.03 (0.84–1.26) 1.02 (0.78–1.34) 0.96 1.01 (0.89–1.16) 0.83
NFKBIB rs2053071 886 0.35 0.87 (0.71–1.06) 1.08 (0.80–1.46) 0.22 0.99 (0.86–1.13) 0.86
  rs12979755 3,098 0.39 0.99 (0.81–1.21) 0.99 (0.75–1.31) 0.99 0.99 (0.87–1.14) 0.93
  rs8108039 3,501 0.19 0.99 (0.81–1.21) 1.40 (0.82–2.38) 0.44 1.05 (0.89–1.24) 0.57
  rs3136642 233 0.39 1.03 (0.84–1.26) 1.05 (0.80–1.39) 0.93 1.03 (0.90–1.17) 0.71
  rs3136645 628 0.20 1.02 (0.83–1.24) 1.23 (0.76–1.99) 0.70 1.05 (0.89–1.24) 0.56
  rs3136646 --- 0.22 0.99 (0.81–1.21) 0.78 (0.51–1.18) 0.49 0.94 (0.80–1.10) 0.41
  1. Adjusted for race, age, area of residence, body mass index, hormone therapy use, oral contraceptive use, parity, and age at first birth; NFKBIA rs3138050 exclude Duke University participants; MAF, minor allele frequency among controls; bold = < 0.05; bp to next represents distance in base pairs between SNPs.