Table 1 Selected Characteristics of Study Participants
From: Polymorphisms in NF-κB Inhibitors and Risk of Epithelial Ovarian Cancer
Mayo Clinic | Duke University | ||||||
|---|---|---|---|---|---|---|---|
Cases (N = 396) | Controls (N = 469) | p-value | Cases (N = 534) | Controls (N = 568) | p-value | ||
Age | Mean (S.D.) yrs | 59.8 (13.3) | 60.1 (13.0) | 0.82 | 54 (11.5) | 54.7 (12.2) | 0.35 |
Race | White | 385 (97.2) | 462 (98.5) | 0.73 | 444 (83.3) | 479 (84.3) | 0.77 |
African American | 3 (0.8) | 2 (0.4) | 70 (13.1) | 74 (13.0) | |||
Asian | 2 (0.5) | 1 (0.2) | 6 (1.1) | 2 (0.4) | |||
Hispanic | 3 (0.8) | 3 (0.6) | 5 (0.9) | 5 (0.9) | |||
Native American | 0 (0.0) | 0 (0.0) | 5 (0.9) | 6 (1.1) | |||
Other | 3 (0.8) | 1 (0.2) | 3 (0.6) | 2 (0.4) | |||
Body mass index | < 23 kg/m2 | 79 (20.7) | 110 (25.1) | 0.02 | 132 (25.4) | 139 (25.2) | 0.29 |
23–26 kg/m2 | 88 (23.1) | 121 (27.6) | 117 (22.5) | 124 (22.5) | |||
26–29 kg/m2 | 98 (25.7) | 112 (25.6) | 106 (20.4) | 136 (24.7) | |||
≥ 29 kg/m2 | 116 (30.4) | 95 (21.7) | 165 (31.7) | 152 (27.6) | |||
Age at menarche | < 12 yrs | 55 (18.7) | 68 (15.8) | 0.46 | 130 (24.4) | 118 (20.8) | 0.44 |
12 yrs | 77 (26.2) | 100 (23.2) | 153 (28.8) | 166 (29.2) | |||
13 yrs | 79 (26.9) | 126 (29.2) | 134 (25.2) | 161 (28.3) | |||
≥ 14 yrs | 83 (28.2) | 137 (31.8) | 115 (21.6) | 123 (21.7) | |||
Oral contraceptive use | Never | 176 (47.6) | 166 (38.4) | < 0.001 | 182 (34.7) | 181 (32.2) | 0.36 |
1–48 months | 98 (26.5) | 92 (21.3) | 158 (30.2) | 160 (28.5) | |||
≥ 48 months | 96 (25.9) | 174 (40.3) | 184 (35.1) | 221 (39.3) | |||
Postmenopausal | Yes | 266 (70.2) | 333 (75.3) | 0.10 | 354 (71.7) | 372 (67) | 0.11 |
No | 113 (29.8) | 109 (24.7) | 140 (28.3) | 183 (33) | |||
Postmenopausal hormone use | Never | 240 (63.8) | 248 (58.6) | 0.31 | 196 (37.7) | 349 (63) | < 0.001 |
1–60 months | 64 (17) | 80 (18.9) | 207 (39.8) | 109 (19.7) | |||
≥ 60 months | 72 (19.1) | 95 (22.5) | 117 (22.5) | 96 (17.3) | |||
Parity, n/Age at first birth, yrs | Nulliparous | 70 (18.3) | 66 (15) | 0.07 | 113 (21.2) | 73 (12.9) | 0.003 |
1–2/≤ 20 yrs | 29 (7.6) | 25 (5.7) | 73 (13.7) | 69 (12.1) | |||
1–2/> 20 yrs | 103 (26.9) | 131 (29.8) | 193 (36.2) | 233 (41) | |||
≥ 3/≤ 20 yrs | 73 (19.1) | 64 (14.5) | 81 (15.2) | 93 (16.4) | |||
≥ 3/> 20 yrs | 108 (28.2) | 154 (35) | 73 (13.7) | 100 (17.6) | |||
Ovarian cancer family history | Yes | 51 (13.3) | 33 (7.4) | 0.01 | 42 (7.9) | 25 (4.4) | 0.02 |
No | 333 (86.7) | 411 (92.6) | 492 (92.1) | 543 (95.6) | |||
Ovarian or breast cancer family history | Yes | 167 (43.5) | 189 (42.6) | 0.79 | 196 (36.7) | 190 (33.5) | 0.26 |
No | 217 (56.5) | 255 (57.4) | 338 (63.3) | 378 (66.5) | |||
Smoking, pack years | None | 233 (64.9) | 285 (68.3) | 0.29 | 297 (57.6) | 291 (53.5) | 0.41 |
<= 20 | 71 (19.8) | 84 (20.1) | 130 (25.2) | 148 (27.2) | |||
> 20 | 55 (15.3) | 48 (11.5) | 89 (17.2) | 105 (19.3) | |||
Education achieved | No diploma | 25 (6.9) | 19 (4.3) | < 0.001 | 53 (9.9) | 69 (12.1) | 0.40 |
High school diploma | 136 (37.4) | 117 (26.4) | 153 (28.7) | 149 (26.2) | |||
Post high school | 203 (55.8) | 307 (69.3) | 327 (61.4) | 350 (61.6) | |||