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Table 1 Selected Characteristics of Study Participants

From: Polymorphisms in NF-κB Inhibitors and Risk of Epithelial Ovarian Cancer

   Mayo Clinic   Duke University  
   Cases (N = 396) Controls (N = 469) p-value Cases (N = 534) Controls (N = 568) p-value
Age Mean (S.D.) yrs 59.8 (13.3) 60.1 (13.0) 0.82 54 (11.5) 54.7 (12.2) 0.35
Race White 385 (97.2) 462 (98.5) 0.73 444 (83.3) 479 (84.3) 0.77
  African American 3 (0.8) 2 (0.4)   70 (13.1) 74 (13.0)  
  Asian 2 (0.5) 1 (0.2)   6 (1.1) 2 (0.4)  
  Hispanic 3 (0.8) 3 (0.6)   5 (0.9) 5 (0.9)  
  Native American 0 (0.0) 0 (0.0)   5 (0.9) 6 (1.1)  
  Other 3 (0.8) 1 (0.2)   3 (0.6) 2 (0.4)  
Body mass index < 23 kg/m2 79 (20.7) 110 (25.1) 0.02 132 (25.4) 139 (25.2) 0.29
  23–26 kg/m2 88 (23.1) 121 (27.6)   117 (22.5) 124 (22.5)  
  26–29 kg/m2 98 (25.7) 112 (25.6)   106 (20.4) 136 (24.7)  
  ≥ 29 kg/m2 116 (30.4) 95 (21.7)   165 (31.7) 152 (27.6)  
Age at menarche < 12 yrs 55 (18.7) 68 (15.8) 0.46 130 (24.4) 118 (20.8) 0.44
  12 yrs 77 (26.2) 100 (23.2)   153 (28.8) 166 (29.2)  
  13 yrs 79 (26.9) 126 (29.2)   134 (25.2) 161 (28.3)  
  ≥ 14 yrs 83 (28.2) 137 (31.8)   115 (21.6) 123 (21.7)  
Oral contraceptive use Never 176 (47.6) 166 (38.4) < 0.001 182 (34.7) 181 (32.2) 0.36
  1–48 months 98 (26.5) 92 (21.3)   158 (30.2) 160 (28.5)  
  ≥ 48 months 96 (25.9) 174 (40.3)   184 (35.1) 221 (39.3)  
Postmenopausal Yes 266 (70.2) 333 (75.3) 0.10 354 (71.7) 372 (67) 0.11
  No 113 (29.8) 109 (24.7)   140 (28.3) 183 (33)  
Postmenopausal hormone use Never 240 (63.8) 248 (58.6) 0.31 196 (37.7) 349 (63) < 0.001
  1–60 months 64 (17) 80 (18.9)   207 (39.8) 109 (19.7)  
  ≥ 60 months 72 (19.1) 95 (22.5)   117 (22.5) 96 (17.3)  
Parity, n/Age at first birth, yrs Nulliparous 70 (18.3) 66 (15) 0.07 113 (21.2) 73 (12.9) 0.003
  1–2/≤ 20 yrs 29 (7.6) 25 (5.7)   73 (13.7) 69 (12.1)  
  1–2/> 20 yrs 103 (26.9) 131 (29.8)   193 (36.2) 233 (41)  
  ≥ 3/≤ 20 yrs 73 (19.1) 64 (14.5)   81 (15.2) 93 (16.4)  
  ≥ 3/> 20 yrs 108 (28.2) 154 (35)   73 (13.7) 100 (17.6)  
Ovarian cancer family history Yes 51 (13.3) 33 (7.4) 0.01 42 (7.9) 25 (4.4) 0.02
  No 333 (86.7) 411 (92.6)   492 (92.1) 543 (95.6)  
Ovarian or breast cancer family history Yes 167 (43.5) 189 (42.6) 0.79 196 (36.7) 190 (33.5) 0.26
  No 217 (56.5) 255 (57.4)   338 (63.3) 378 (66.5)  
Smoking, pack years None 233 (64.9) 285 (68.3) 0.29 297 (57.6) 291 (53.5) 0.41
  <= 20 71 (19.8) 84 (20.1)   130 (25.2) 148 (27.2)  
  > 20 55 (15.3) 48 (11.5)   89 (17.2) 105 (19.3)  
Education achieved No diploma 25 (6.9) 19 (4.3) < 0.001 53 (9.9) 69 (12.1) 0.40
  High school diploma 136 (37.4) 117 (26.4)   153 (28.7) 149 (26.2)  
  Post high school 203 (55.8) 307 (69.3)   327 (61.4) 350 (61.6)  
  1. Data are counts (percentage) unless otherwise indicated. Counts do not total to 1,967 subjects due to missing data for some variables. P-values are from within-sites tests of case-control differences; continuous variables (t-test) and categorical variables (Chi square test). Family history, in first or second degree relative; bold indicates p < 0.05.