Table 1 Sensitivity levels to G418 killing and success/failure in IFN-γ-transduction of a panel of NPC cell lines/sublines
Cell line/clonal subline | Sensitivity to G418 killing (minimal dose for 100% cell kill) (μg/ml) | Success in IFN-γ gene transduction via a retroviral vector |
|---|---|---|
Derived from a primary lesion | ||
NPC039 | 600 | Yes |
NPC076 | 600 | Yes |
NPC-BR | 300 | Yes |
CNE-1 | 600 | No |
CNE-2 | 600 | No |
NPC039-2E2* | 600 | Yes |
NPC039-6A1* | 600 | Yes |
NPC039-7B2* | 600 | Yes |
NPC039-9A2* | 600 | Yes |
Derived from a metastatic lesion | ||
CNE-3 (ascites) | 18,000 | No |
NPC-AS1 (ascites) | 9,000 | No |
NPC-BM1 (bm§) | 18,000 | Yes |
NPC-BM2 (bm) | 12,000 | No |
NPC-BM3 (bm) | 15,000 | Yes |