Figure 1
From: The 14-3-3σ gene promoter is methylated in both human melanocytes and melanoma
CpG island promoter region of the 14-3-3 gene. The CpG Island Searcher Program (Takai et al, 2003) identified a CpG island within the 14-3-3σ gene, downstream of the transcriptional start site. Arrow represents the transcriptional start site. Blue line depicts the CpG island. Red line indicates the area analyzed by methylation-specific sequencing and black lines represent the location of the methylation specific PCR primers.