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Table 2 Frequency of 5'-UTR loss of heterozygosity (LOH) in low esophagus, IM, dysplasia and BA tissues

From: Loss of heterozygosity at thymidylate synthase locus in Barrett's metaplasia, dysplasia, and carcinoma sequences

Low esophagus (LE) (n = 37)      
Genotype in normal tissues 2R/2R 2R/3R 3R/3R
Number of samples 8 22 7
Genotype in LE tissues   2R/loss 2R/3R 3R/loss  
Number of samples   0 22 0  
Frequency   0% 100% 0%  
Intestinal metaplasia (IM) (n = 29)      
Genotype in normal tissues 2R/2R 2R/3R 3R/3R
Number of samples 3 21 5
Genotype in IM tissues   2R/loss 2R/3R 3R/loss  
Number of samples   5 15 1  
Frequency   23.80% 71.40% 4.80%  
Dysplasia (n = 13)      
Genotype in normal tissues 2R/2R 2R/3R 3R/3R
Number of samples 4 7 2
Genotype in dysplasia tissues   2R/loss 2R/3R 3R/loss  
Number of samples   1 5 1  
Frequency   14.30% 71.40% 14.30%  
Barrett associated adenocarcinoma (BA) (n = 44)      
Genotype in normal tissues 2R/2R 2R/3R 3R/3R
Number of samples 15 25 4
Genotype in BA tissues   2R/loss 2R/3R 3R/loss  
Number of samples   3 15 7  
Frequency   12% 60% 28%