Table 2 Adverse events based on worst grade toxicity experienced during preoperative and postoperative chemotherapy.
Adverse Event | Preoperative Chemotherapy (n = 35) | Postoperative Chemotherapy (n = 22) | ||
|---|---|---|---|---|
| Â | Grade 1/2 N (%) | Grade 3/4 N (%) | Grade 1/2 N (%) | Grade 3/4 N (%) |
Gastrointestinal | Â | Â | Â | Â |
   Nausea/vomiting | 25 [71] | 0 (0) | 17 (77) | 0 (0) |
   Diarrhea | 19 (54) | 2 (6) | 11 (50) | 1 (5) |
   Constipation | 8 (23) | 1 (3) | 8 (36) | 0 (0) |
   Anorexia | 7 (20) | 0 (0) | 3 (14) | 0 (0) |
   Mucositis/stomatitis | 11 (31) | 0 (0) | 8 (36) | 0 (0) |
   Small Bowel Perforation | 0 (0) | 1 (3) | 0 (0) | 0 (0) |
   Other: heartburn, dyspepsia, gas pain, taste alteration, dysgeusia, hiccups, dry mouth, abdominal cramping, dysphagia | 12 (34) | 0 (0) | 11 (50) | 0 (0) |
Constitutional | Â | Â | Â | Â |
   Fatigue or lethargy or insomnia | 30 (86) | 0 (0) | 16 (73) | 0 (0) |
   Diaphoresis/flushing | 4 (11) | 0 (0) | 1 (5) | 0 (0) |
   Other: fever, cough, cold | 3 (9) | 0 (0) | 1 (5) | 0 (0) |
Infection | 10 (29) | 2 (6) | 5 (23) | 2 (9) |
Pain | 7 (20) | 0 (0) | 7 (32) | 0 (0) |
Laboratory: Hematological | Â | Â | Â | Â |
   Lymphopenia | 1 (3) | 2 (6) | 2 (9) | 0 (0) |
   Neutropenia | 12 (34) | 4 (11) | 8 (36) | 9 (41) |
   Anemia | 13 (37) | 0 (0) | 9 (41) | 0 (0) |
   Thrombocytopenia | 4 (11) | 0 (0) | 8 (36) | 0 (0) |
Laboratory: Biochemistry | Â | Â | Â | Â |
   Elevated liver function tests: AST, ALT, bilirubin, alkaline phosphatase, LDH | 6 (17) | 0 (0) | 5 (23) | 0 (0) |
   Elevated creatinine | 2 (6) | 0 (0) | 1 (5) | 0 (0) |
   Decreased protein/albumin | 2 (6) | 0 (0) | 2 (9) | 0 (0) |
   Coagulation abnormalities: INR/PTT | 0 (0) | 1 (3) | 0 (0) | 1 (5) |
   Miscellaneous electrolyte and metabolic disturbances: hypermagnesemia, elevated phosphorous, hypocalcemia, hypokalemia | 2 (6) | 1 (3) | 1 (5) | 0 (0) |
Thromboembolic | Â | Â | Â | Â |
   Deep vein thrombosis | 0 (0) | 5 (14) | 0 (0) | 4 (18) |
   Acute myocardial infarction | 0 (0) | 1 (3) | 0 (0) | 0 (0) |
Dermatology/Skin | Â | Â | Â | Â |
   Erythemia, rash, desquamation | 7 (20) | 0 (0) | 5 (23) | 0 (0) |
   Alopecia | 7 (20) | 0 (0) | 4 (18) | 0 (0) |
Miscellaneous: Other | Â | Â | Â | Â |
   Blurred vision/eye irritation | 6 (17) | 0 (0) | 4 (18) | 0 (0) |
   Mood alteration: agitation, anxiety, depression, hyperactivity | 7 (20) | 2 (6) | 5 (23) | 0 (0) |