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Table 2 Adverse events based on worst grade toxicity experienced during preoperative and postoperative chemotherapy.

From: A phase II experience with neoadjuvant irinotecan (CPT-11), 5-fluorouracil (5-FU) and leucovorin (LV) for colorectal liver metastases

Adverse Event Preoperative Chemotherapy (n = 35) Postoperative Chemotherapy (n = 22)
  Grade 1/2
N (%)
Grade 3/4
N (%)
Grade
1/2
N (%)
Grade 3/4
N (%)
Gastrointestinal     
   Nausea/vomiting 25 [71] 0 (0) 17 (77) 0 (0)
   Diarrhea 19 (54) 2 (6) 11 (50) 1 (5)
   Constipation 8 (23) 1 (3) 8 (36) 0 (0)
   Anorexia 7 (20) 0 (0) 3 (14) 0 (0)
   Mucositis/stomatitis 11 (31) 0 (0) 8 (36) 0 (0)
   Small Bowel Perforation 0 (0) 1 (3) 0 (0) 0 (0)
   Other: heartburn, dyspepsia, gas pain, taste alteration, dysgeusia, hiccups, dry mouth, abdominal cramping, dysphagia 12 (34) 0 (0) 11 (50) 0 (0)
Constitutional     
   Fatigue or lethargy or insomnia 30 (86) 0 (0) 16 (73) 0 (0)
   Diaphoresis/flushing 4 (11) 0 (0) 1 (5) 0 (0)
   Other: fever, cough, cold 3 (9) 0 (0) 1 (5) 0 (0)
Infection 10 (29) 2 (6) 5 (23) 2 (9)
Pain 7 (20) 0 (0) 7 (32) 0 (0)
Laboratory: Hematological     
   Lymphopenia 1 (3) 2 (6) 2 (9) 0 (0)
   Neutropenia 12 (34) 4 (11) 8 (36) 9 (41)
   Anemia 13 (37) 0 (0) 9 (41) 0 (0)
   Thrombocytopenia 4 (11) 0 (0) 8 (36) 0 (0)
Laboratory: Biochemistry     
   Elevated liver function tests: AST, ALT, bilirubin, alkaline phosphatase, LDH 6 (17) 0 (0) 5 (23) 0 (0)
   Elevated creatinine 2 (6) 0 (0) 1 (5) 0 (0)
   Decreased protein/albumin 2 (6) 0 (0) 2 (9) 0 (0)
   Coagulation abnormalities: INR/PTT 0 (0) 1 (3) 0 (0) 1 (5)
   Miscellaneous electrolyte and metabolic disturbances: hypermagnesemia, elevated phosphorous, hypocalcemia, hypokalemia 2 (6) 1 (3) 1 (5) 0 (0)
Thromboembolic     
   Deep vein thrombosis 0 (0) 5 (14) 0 (0) 4 (18)
   Acute myocardial infarction 0 (0) 1 (3) 0 (0) 0 (0)
Dermatology/Skin     
   Erythemia, rash, desquamation 7 (20) 0 (0) 5 (23) 0 (0)
   Alopecia 7 (20) 0 (0) 4 (18) 0 (0)
Miscellaneous: Other     
   Blurred vision/eye irritation 6 (17) 0 (0) 4 (18) 0 (0)
   Mood alteration: agitation, anxiety, depression, hyperactivity 7 (20) 2 (6) 5 (23) 0 (0)