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Table 1 Patient characteristics at time of accrual.

From: A phase II experience with neoadjuvant irinotecan (CPT-11), 5-fluorouracil (5-FU) and leucovorin (LV) for colorectal liver metastases

Parameter

Total Number of Patients

35

Age

59 ± 8 years

Gender

 

   Male

24 (69%)

   Female

11 (31%)

Site of Primary Tumor

 

   Colon

22 (63%)

   Rectosigmoid

7 (20%)

   Rectum

6 (17%)

Previous Treatment for Primary Tumor

 

   Chemotherapy

11 (31%)

   Radiotherapy

6 (17%)

Initial Staging

 

   Stage I

1 (3%)

   Stage II

4 (11%)

   Stage III

9 (26%)

   Stage IV (ie: synchronous liver metastases)

21 (60%)

Metachronous liver metastases

14 (40%)

   Median disease-free interval (range)

24 mo (4–61 mo)

Mean Number of Liver Lesions

2 ± 3

   Solitary metastasis

21 (60%)

   > 1 metastases

14 (40%)

Size of Largest Liver Lesion

5.0 ± 2.6 cm

   ≤ 5 cm

21 (60%)

   > 5 cm

14 (40%)

Carcinoembryogenic Antigen

31 ± 41 ng/mL