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Table 5 Logistic regressions for association between leucopenia, anaemia and thrombocytopenia and B symptoms and other potential predictor variables.

From: Inflammatory (B) symptoms are independent predictors of myelosuppression from chemotherapy in Non-Hodgkin Lymphoma (NHL) patients – analysis of data from a British National Lymphoma Investigation phase III trial comparing CHOP to PMitCEBO

  Univariate OR# p Multivariate OR# p
  (95% CI@)   (95% CI@)  
Leucopenia *     
B symptoms present 2.0 (1.5–2.8) < 0.001 1.7 (1.2–2.4) 0.005
Performance status level 2–4 3.0 (2.1–4.3) < 0.001 2.2 (1.5–3.3) < 0.001
Bone marrow aspirate positive 2.3 (1.3–4.1) 0.006 2.2 (1.2–4.0) 0.015
Age 75 years or older 1.8 (1.3–2.6) 0.001 2.1 (1.4–3.1) < 0.001
PMitCEBO given 2.4 (1.7–3.3) < 0.001 2.1 (1.5–3.0) < 0.001
GCSF given 0.6 (0.4–0.8) 0.001 0.5 (0.4–0.8) 0.001
Bone marrow trephine positive 2.1 (1.3–3.4) 0.002 -  
Stage 3 or 4 1.8 (1.3–2.5) < 0.001 -  
LDH elevated 1.4 (1.02–2.0) 0.038 -  
Anaemia **     
B symptoms present 2.3 (1.2–4.3) 0.013 2.3 (1.1–4.7) 0.025
LDH elevated 2.9 (1.3–6.7) 0.011 2.6 (1.1–6.1) < 0.001
GCSF given 2.6 (1.3–4.9) 0.004 2.3 (1.1–4.5) 0.020
Bone marrow aspirate positive 2.5 (1.1–5.8) 0.030 -  
Performance status level 2–4 2.1 (1.2–3.9) 0.013 -  
Bone marrow trephine positive 1.9 (0.9–4.1) 0.088 -  
Thrombocytopenia ***     
B symptoms present 2.7 (1.5–4.8) 0.001 -  
Performance status level 2–4 4.8 (2.8–8.2) < 0.001 4.8 (2.5–9.2) < 0.001
LDH elevated 6.7 (2.6–17.0) < 0.001 4.0 (1.5–10.4) 0.005
Bone marrow trephine positive 2.8 (1.5–5.2) 0.001 2.9 (1.4–5.8) 0.003
PMitCEBO given 0.6 (0.4–1.0) 0.058 0.5 (0.3–0.9) 0.032
Stage 3 or 4 3.2 (1.6–6.2) 0.001 -  
Bone marrow aspirate positive 2.7 (1.4–5.6) 0.005 -  
Age 75 years or older 2.0 (1.2–3.4) 0.011 -  
GCSF given 1.7 (1.0–2.8) 0.058 -  
  1. * The multivariate model is for 560 patients with complete data on all variables included in it.
  2. ** The multivariate model is for 597 patients with complete data on all variables included in it.
  3. *** The multivariate model is for 522 patients with complete data on all variables included in it.
  4. # Odds ratio
  5. @ Confidence interval