Table 4 Patients with grade 3 or 4 anaemia, leucopenia or thrombocytopenia by demographic, treatment and clinical variables. Number (per cent).
Variable | Category | n | Grade 3/4 leucopenia | p | Grade 3/4 anaemia | p | Grade 3/4 thrombocytopenia | p |
|---|---|---|---|---|---|---|---|---|
B symptoms | No | 311 | 124 (39.9) | < 0.001 | 14 (4.5) | 0.011 | 17 (5.5) | < 0.001 |
Yes | 353 | 203 (57.5) | 34 (9.6) | 48 (13.6) | ||||
Sex | Female | 311 | 159 (51.1) | 0.363 | 25 (8.0) | 0.450 | 33 (10.6) | 0.504 |
Male | 353 | 168 (47.6) | 23 (6.5) | 32 (9.1) | ||||
Age | < 75 years | 496 | 226 (45.6) | 0.001 | 33 (6.7) | 0.324 | 40 (8.1) | 0.010 |
≥ 75 years | 168 | 101 (60.1) | 15 (8.9) | 25 (14.9) | ||||
Chemotherapy | CHOP | 334 | 129 (38.6) | < 0.001 | 27 (8.1) | 0.392 | 40 (12.0) | 0.056 |
PMitCEBO | 330 | 198 (60.0) | 21 (6.4) | 25 (7.6) | ||||
GCSF | No | 330 | 184 (55.8) | < 0.001 | 14 (4.2) | 0.003 | 25 (7.6) | 0.056 |
Yes | 334 | 143 (42.8) | 34 (10.2) | 40 (12.0) | ||||
Stage | Stage 0–2 | 246 | 99 (40.2) | < 0.001 | 14 (5.7) | 0.240 | 11 (4.5) | < 0.001 |
Stage 3–4 | 418 | 228 (54.5) | 34 (8.1) | 54 (12.9) | ||||
Performance status | Level 0–1 | 470 | 197 (41.9) | < 0.001 | 27 (5.7) | 0.012 | 25 (5.3) | < 0.001 |
Level 2–4 | 183 | 125 (68.3) | 21 (11.5) | 39 (21.3) | ||||
LDH (mU/L) | Normal | 216 | 96 (44.4) | 0.038 | 7 (3.2) | 0.008 | 5 (2.3) | < 0.001 |
Elevated | 381 | 203 (53.3) | 34 (8.9) | 52 (13.6) | ||||
Bone marrow aspirate | Negative | 508 | 248 (48.8) | 0.005 | 31 (6.1) | 0.046* | 45 (8.9) | 0.004 |
Positive | 57 | 39 (68.4) | 8 (14.0) | 12 (21.1) | ||||
Bone marrow | Negative | 487 | 228 (46.8) | 0.001 | 30 (6.2) | 0.083 | 40 (8.2) | 0.001 |
Trephine | Positive | 89 | 58 (65.2 | 10 (11.2) | 18 (20.2) |