Figure 3

Aromatase, PII, PI.3 and FSHR expression in ovarian tissue of BRCA1 mutation carriers and control women. Transcript expression of (a) total aromatase, (b) promoter II-specific (c) promoter I.3-specific and (d) FSHR in tissue derived from prophylactic oophorectomy in BRCA1 mutation carriers and age-matched controls. Data has been normalized to 18S expression for each sample (n = 6 subjects per group, RT-PCR performed in triplicate for each sample). The mean expression level for each subject group is indicated with a horizontal line and *P < 0.05, **P < 0.001 are significantly different versus control.