Figure 1

Aromatase and its promoter usage in breast adipose of BRCA1 mutation carriers and control subjects. Relative expression levels of (a) total aromatase transcripts (b) promoter II-specific transcripts (c) promoter I.3-specific transcripts and (d) promoter I.4-specific transcripts in breast adipose tissue samples from control women and prophylactic and therapeutic mastectomy samples from BRCA1 mutation carriers. Data has been normalized to 18S expression for each sample (n = 10 subjects per group, RT-PCR performed in triplicate for each sample). The mean expression level for each subject group is indicated with a horizontal line and *P < 0.05, **P < 0.01 and ***P < 0.0001 are significantly different versus control.